Week 10 of the 2021 NFL season wraps up with Monday Night Football from Levi’s Stadium in Santa Clara, California, so here’s the best Los Angeles Rams vs. San Francisco betting pick along with the latest odds update for this NFC West showdown.

The Rams are listed as 4-point road favorites on BetDSI Sportsbook, while the 49ers are +171 moneyline underdogs with a total of 49.0 points. Last year, the Niners swept the Rams and covered on both occasions.  

The Rams stopped their winning streak in Week 9 

The Los Angeles Rams dropped to 7-2 SU and 4-5 ATS on the season following an upsetting 28-16 defeat to the Tennessee Titans this past Sunday. They put an end to a four-game winning streak thanks to a horrible second-quarter performance by Matthew Stafford and the Rams’ offensive line.

Stafford threw a couple of interceptions and allowed the Titans to score a pair of easy touchdowns, including Kevin Byard’s pick-six. The Rams couldn’t recover from a shocking 21-3 deficit at halftime, while Stafford finished 31-of-48 for 294 yards, a TD, and two interceptions.

Los Angeles failed to surpass a 20-point mark for the first time since Week 4 and a 37-20 defeat to the Arizona Cardinals. The Rams are now tallying 29.0 points per game (5th in the NFL) while surrendering 21.8 in a return (tied-10th).

The Niners failed to cope with a short-handed Cardinals        

The San Francisco 49ers were listed as firm 5.5-point home favorites to beat Arizona in Week 9, but they completely disappointed and fell to 3-5 SU and 2-6 ATS on the season. The Niners suffered a heavy 31-17 defeat, allowing Colt McCoy to dominate the game and complete 22 of his 26 passing attempts for 249 yards and a TD.

The 49ers couldn’t stop James Conner either, so Arizona finished with 437 total yards, 100 more than San Francisco. Jimmy Garoppolo went 28-of-40 for 326 yards, a couple of touchdowns, and an interception, while George Kittle had six catches for 101 yards and a TD.

Kittle and Brandon Aiyuk lost a fumble each, and the Niners will have to take care of the ball if they want to stay alive in the playoff chase. San Francisco is scoring 23.1 points per game (18th in the NFL) on 365.6 total yards (13th) while yielding 25.3 points in a return (25th) on 338.1 total yards (8th).


LA Rams:

  • 10-5 ATS in the last 15 games against the NFC 

San Francisco:

  • 1-5 ATS in the last six games overall
  • 1-4 ATS in the last five games against the NFC
  • 2-10 ATS in the last 12 games at home  

Los Angeles Rams vs. San Francisco 49ers Pick

The 49ers are in a must-win situation, and I’m expecting them to play much better than they did last week against Arizona. However, the Rams will be fired up to bounce back from that awful display against Tennessee, and Los Angeles certainly possesses more firepower on both sides of the ball than San Francisco.

The Rams lead the NFL in the percentage of drives ending in a score (49.5%), while the Niners are 20th in the league (37.6%). San Francisco has dominated the Rams over the last few years, going 8-3 SU and ATS in their previous 11 H2H duels, but the 49ers are only 1-11 SU and 2-10 ATS in their last 12 outings at home.

Pick: Take Los Angeles Rams -4.0 at -110                    

The Total:

Three of the last four meetings between the Rams and 49ers went in the under, but I’m not expecting a low-scoring affair this Sunday. San Francisco has allowed 22 or more points in each but one of its last six showings, while I’ve already mentioned the Rams’ recent scorelines.

The over is 7-3-1 in the Rams’ previous 11 outings at any location, and it is 6-3 in the 49ers’ last nine games overall.

Pick: Go over 49.0 points at -110