One of the most intriguing NFL games of Week 7 will be played on Sunday, October 23, and here you can read the Chiefs vs. 49ers betting pick and odds.

Both Kansas City and San Francisco are looking to return to winning ways when they face at Levi’s Stadium. The Chiefs are slight -2.5 favorites on MyBookie Sportsbook, while the total is set at 48.5 points. These inter-conference rivals haven’t met since Super Bowl LIV when the Chiefs won 31-20.

Chiefs dropped a lead late in a loss to the Bills

The Kansas City Chiefs (4-2, 2-4 ATS) were close to getting the third consecutive win when they hosted the Buffalo Bills, but the visitors scored a late touchdown and came from behind to win 24-20. Kansas City had a lead until 1:04 remaining, but judging by the numbers in this game, they didn’t deserve to win as the Bills wanted it more.

Patrick Mahomes completed 25 of 40 passes for 338 yards, two touchdowns, and two interceptions. JuJu Smith-Schuster was excellent through the air and led the team in receiving yards with 133 and a TD on five catches. Mecole Hardman also recorded a receiving touchdown, while Travis Kelce caught eight passes for 108 yards. The run offense didn’t provide a lot of yards for the Chiefs, only 68 on 18 carries. Defensively, Nick Bolton was strong with a game-high 13 tackles.

CB Rashad Fenton missed the last game with a hamstring issue, and it is unclear if he will suit up Sunday against the 49ers.

Turnovers cost the 49ers in a loss to the Falcons

The San Francisco 49ers (3-3, 3-3 ATS) were also searching for the third straight win after defeating the Los Angeles Rams and Carolina Panthers, but they succumbed to a 28-14 loss to the Atlanta Falcons on the road. San Francisco did have more total yards (346-289) and first downs (21-18), but the Niners committed three turnovers opposite Atlanta’s zero.

Jimmy Garoppolo completed 29 of 41 passes for 296 yards, two touchdowns, and two interceptions. Brandon Aiyuk and George Kittle posted identical numbers as they recorded 83 yards apiece on eight receptions, but the former was on the receiving end of both Garoppolo’s TD passes. Deebo Samuel added 79 yards on seven catches, while the run offense was ineffective with only 50 yards on 16 attempts. Fred Warner was the most active on defense with team-high ten tackles.

T Trent Williams (ankle) is out indefinitely. DT Arik Armstead (foot), T Mike McGlinchey (calf), and DE Nick Bosa (groin) are questionable to play on Sunday against Kansas City.


Kansas City:

  • 1-4 ATS in the last five games overall
  • 0-5 ATS in the last five games after allowing more than 250 yards passing in their previous game

San Francisco:

  • 6-0 ATS in the last six home games
  • 6-1 ATS in the last seven games following an ATS loss
  • 8-3 ATS in the last 11 games overall

Kansas City Chiefs and San Francisco 49ers Pick  

The Chiefs do have the highest-scoring offense in the NFL, but it’s going to be all about defense in this duel. While Kansas City is scoring 29.8 points per game, San Francisco is barely in the top 20 with 20.3 ppg, but the Niners’ defense is the second-best in the league as it allows just 14.8 ppg. They are particularly good at home; in two games at Levi’s Stadium this year, Frisco allowed only 16 points in total to the divisional rivals Rams and Seahawks. I don’t expect the 49ers to keep the Chiefs to a single digit in this one, but I do back their D to prevail. Even if they lose, I don’t believe the visitors will beat them by more than a field goal difference.

Pick: Take the 49ers at +3.5 (-135)

The Total

The Chiefs had problems against the Buffalo Bills, who have the best defense in the country, and now will face the second-best D. I expect more struggles for Mahomes and his offense, and I think the Niners will keep the visitors to 20-25 points. I don’t expect much from the 49ers’ offense, but they will have chances to do damage against the defense that allows 24.8 ppg. Under is 12-2 in the 49ers’ last 14 games overall; Under is 4-0 in San Francisco’s previous four home games, while Under is 13-3 in the 49ers’ last 16 games following an ATS loss.

Pick: Go Under 48.5 points (-110)