The NFL continues with Week 13 and this inter-conference matchup is scheduled for Sunday, December 4, so make sure you get the best Jaguars vs. Lions betting pick and odds.

Detroit is hoping to return to winning ways when they welcome Jacksonville at Ford Field. The Jaguars are slight 1-point favorites on BookMaker Sportsbook, while the total is set at 51.5 points. These inter-conference rivals haven’t met since 2020 when the Lions won 34-16 in Jacksonville.

Jaguars edged the Ravens with a late TD and a two-point conversion

The Jacksonville Jaguars (4-7-0, 4-6-1 ATS) went through a rough period of five consecutive losses, but they bounced back with two wins in three games. The most recent one was an upset home victory over the Baltimore Ravens. Jacksonville trailed 27-20 in the final minute of the tilt when Marvin Jones Jr. scored a touchdown and the Jags opted for a two-point conversion, which was successful, so the hosts snatched a 28-27 win.

Trevor Lawrence completed 29 of 37 passes for season-high 321 yards and career-high three touchdowns. It was the best game of Lawrence’s young career as he connected with JaMycal Hasty, Jamal Agnew, and Marvin Jones Jr. in the end zone. Zay Jones didn’t record a receiving touchdown but he posted a career-high 145 yards on 11 catches. Another personal record was broken in this win, but this one was on the defensive end as Foyesade Oluokun got a career-high 18 tackles.

WR Calvin Ridley (suspension) and LB K’Lavon Chaisson (knee) are out indefinitely. RB Travis Etienne (foot) is questionable to play against Detroit on Sunday.

Lions lost to the Bills in the dying seconds

The Detroit Lions (4-7-0, 7-4-0 ATS) nearly recorded their fourth consecutive win after defeating the Packers, Bears, and Giants. They had a 3-point lead in the fourth quarter against the Buffalo Bills at home and then tied the game at 25-25 with just 23 seconds to go. However, that was enough for Josh Allen to set up a game-winning field goal for Tyler Bass, who was accurate from 45 yards.

Jared Goff completed 23 of 37 passes for 240 yards and two touchdowns. Amon-Ra St. Brown was impressive in the air with a game-high 122 yards and a touchdown on nine receptions, while DJ Chark also found the end zone. Jamaal Williams was solid on the ground as he had 66 yards and a score on 18 carries. Defensively, James Houston added a pair of sacks, while Alex Anzalone led the team with nine tackles.

WR Quintez Cephus (foot) is out indefinitely and will not be available for Sunday’s clash with Jacksonville. C Evan Brown (ankle), CB Jeff Okudah (concussion), G Jonah Jackson (concussion), and DE Josh Paschal (knee) are questionable.



  • 5-13-1 ATS in the last 19 games overall
  • 1-7-1 ATS in the last nine road games
  • 2-6-1 ATS in the last nine games following an ATS win


  • 4-0 ATS in the last four games overall
  • 8-2 ATS in the last ten home games
  • 5-1 ATS in the last six games following an ATS win

Jacksonville Jaguars vs. Detroit Lions Pick  

Detroit is playing its best football of the season, and even though the Lions have the worst defense in the NFL that is allowing 28.2 points per game, their offense is in the top 10. Jared Goff’s chemistry with his receivers is improving, which was visible on the field over the last month, and given that Jacksonville’s pass defense is not good (248.1 ypg allowed to the opposing receivers), I am backing the hosts to have an edge in this one. Even though I usually lean toward stronger defenses, in this particular case I am going with a higher-scoring offense in a combo with better form and home-field advantage.

Pick: Take the Lions at +2.5 (-130)

The Total

While I am backing Detroit’s offense over Jacksonville’s, we can’t ignore the fact that the Lions do have the weakest defense in the league. They are surrendering a league-high 414.5 total yards per game, and are among the worst five teams in both pass and rush yards allowed to opponents. Over is 6-1 in the Jaguars’ last seven road games; Over is 9-4 in the Lions’ previous 13 games overall, while Over is 6-1 in Detroit’s last seven games following an ATS win.

Pick: Go Over 49.5 points (-133)