San Francisco and Seattle will close down their 2021 regular-season series Sunday, December 5, so we’re breaking down their NFC West showdown at Lumen Field in Seattle to get you the best 49ers vs. Seahawks betting pick and odds.

Back in Week 4, the Seahawks beat the Niners 28-21 as 2.5-point road underdogs. Seattle is undefeated in three straight encounters with San Francisco, but the Seahawks are listed as 3-point home underdogs this time around. The totals sit at 45.5 points on MyBookie Sportsbook

The Niners shoot for their fourth straight victory  

The San Francisco 49ers are rolling on a three-game winning streak following a 34-26 home victory to the Minnesota Vikings in Week 12. They covered a 4-point spread and hit the 30-point mark for the third straight week.

Deebo Samuel suffered a groin injury last weekend and will miss the clash against the Seahawks. He’s been spectacular over the previous three games, scoring five touchdowns in the process. Jimmy Garoppolo has thrown for five touchdowns and an interception in that three-game stretch, as the Niners continue to improve on the offensive end.

George Kittle had only one reception last Sunday, but since his return from the injury list, the Niners’ offensive line has dominated its opponents. San Francisco has registered a whopping 142 carries for 535 yards over its last three contests.

The Seahawks’ season is over       

The Seattle Seahawks extended their losing streak to three games last Monday, suffering a tough 17-15 defeat at the Washington Football Team. They fell to 3-8 SU and 5-6 ATS on the season, so the Seahawks will almost certainly miss the postseason for the first time since 2017.

In three outings since their bye week, the Seahawks have scored only 28 points in total. Their rushing offense is non-existence, and the Seahawks posted a paltry 34 yards on 12 totes against Washington. Russell Wilson went 20-of-31 for 247 yards and a couple of touchdowns but failed to complete a two-point conversion with 15 seconds left on the clock in the fourth quarter.

Tyler Lockett had three receptions for 96 yards against the Football Team. He hasn’t scored a TD since Week 2, while D.K. Metcalf has accounted for eight catches and no touchdowns over the previous three weeks.


San Francisco:

  • 4-1 ATS in the last five games overall
  • 11-6 ATS in the last 17 games on the road


  • 1-4 ATS in the last five games against the NFC West

San Francisco vs. Seattle Seahawks Pick

The momentum is clearly on the Niners’ side, so I won’t hesitate to lay three points with the visitors. The Seahawks look like a bad team that cannot wait for the end of the season, while the 49ers desperately need a win, as they continue to battle for the playoff spot.

San Francisco’s offense has been terrific as of late. The Niners should dominate the Seahawks, who allow 124.9 rushing yards per contest (tied-23rd in the NFL).

Pick: Take San Francisco 49ers -3.0 at -110                    

The Total:

Eight of the Seahawks’ last nine games have gone under the total along with a push. I’ve mentioned how bad their offense has been all season long, while Seattle’s defense is trying its best, allowing 20.5 points per game (7th in the NFL) despite 399.0 total yards allowed per contest (32nd).

The line is a tricky one at 45.5 points, so I would go with the Niners to cover. When it comes to the totals, the under seems like a way to go, but the over is 5-1-1 in the last seven encounters between the 49ers and Seahawks.

Pick: Go under 45.5 points at -110