The NFL is giving us this NFC Championship Game on Sunday, January 29, which will take place in Philadelphia, and here you can read the best 49ers vs. Eagles betting pick and odds.

San Francisco is searching for the 13th consecutive win when they visit Philadelphia at Lincoln Financial Field. The Eagles are -2.5 favorites on MyBookie Sportsbook, while the total is set at 45.5 points. These conference rivals will face for the first time since 2019.

49ers beat the Cowboys in a low-scoring affair

The San Francisco 49ers (15-4-0, 13-6-0 ATS) had a harder job against the Dallas Cowboys in the NFC Divisional Round tilt at home than they did against the Seattle Seahawks in the Wild Card. Still, the 49ers managed to get a 19-12 victory despite failing to impress offensively. Although the Niners scored just one touchdown, they were excellent defensively and also limited Dallas to one touchdown. San Francisco forced a couple of turnovers and made one in return.

Brock Purdy completed 19 of 29 passes for 214 yards. Christian McCaffrey scored the lone TD for the 49ers in this win; he finished with 35 yards on ten rushing attempts and added 22 yards on six catches. Elijah Mitchell led all the runners with 51 yards on 14 carries, while George Kittle was the most productive receiver with 95 yards on five receptions. Defensively, Fred Warner led the team with nine tackles.

QB Jimmy Garoppolo (foot), WR Jordan Matthews (knee), and QB Trey Lance (ankle) are out for the season. DE Charles Omenihu (oblique) and CB Ambry Thomas (ankle) are questionable to face Philly on Sunday.

Eagles didn’t give a chance to the Giants in a blowout win

The Philadelphia Eagles (15-3-0, 9-9-0 ATS) topped the NFC in the regular season and earned a bye week in the Wild Card. The Eagles had enough time to rest and prepare for the clash against the divisional foes New York Giants and destroyed them 38-7. Philadelphia was up 28-0 at halftime and it was evident that the G-Men cannot return from such a deficit. The visitors did draw the first blood in the second half and scored a TD, but that was all from New York. The Eagles dominated total yards (416-227), first downs (26-13), and possession (35:43-24:17), while the hosts forced one turnover and committed none on the other end.

Jalen Hurts completed 16 of 24 passes for 154 yards and two touchdowns. He also added one rushing TD. Kenneth Gainwell had the game of his career as he led all the runners with 112 yards and a score on 12 carries. Miles Sanders added 90 yards on 17 attempts, while Boston Scott scored a rushing touchdown. In the air, DeVonta Smith and Dallas Goedert each produced a TD and combined for 119 yards on 11 receptions. On defense, Josh Sweat and Haason Reddick had 1.5 sacks apiece.

DE Robert Quinn (knee) and DE Derek Barnett (ACL) are out for the year.


San Francisco:

  • 23-8 ATS in the last 31 games overall
  • 5-0 ATS in the last five playoff games
  • 5-0 ATS in the last five games after allowing less than 15 points in their previous game


  • 1-4 ATS in the last five games overall
  • 1-4 ATS in the last five vs. NFC rivals
  • 1-5 ATS in the last six games after allowing less than 150 yards passing in their previous game

San Francisco 49ers vs. Philadelphia Eagles Pick

Philadelphia perhaps had the joint-best record in the regular season and dismantled the Giants in the previous game, but I think the Niners are going to give the Eagles a real test on Sunday. The Eagles’ offense has been better thus far as it scores 28.1 points per game opposite San Francisco’s 26.5 ppg. However, the 49ers have the best defense in the NFL and they proved it in the most recent clash against Dallas. Despite the fact that the Eagles are scoring more points than the Niners, I believe the visitors have more offensive weapons and I am backing them to get a win here.

Pick: Take the 49ers at +2.5 (-105)

The Total

San Francisco’s D is going to prevail in this one. The 49ers kept the opponents to 17 points or below in nine of the previous 12 games, and we know that defenses win championships, which is why I think this one is not going to be a high-scoring affair. Under is 4-0 in the last four H2H meetings; Under is 7-0 in the 49ers’ previous seven playoff road games, while Under is 15-5-1 in the Eagles’ last 21 playoff games.

Pick: Go Under 46.5 points (-120)