The Week 7 of the NFL will kick off with an NFC encounter in Arizona on Thursday, October 20, and here you can get the best Saints vs. Cardinals betting pick and odds.

Arizona is looking to avoid the third consecutive defeat when they host New Orleans at State Farm Stadium. The Cardinals are slight -1.5 favorites on Bovada Sportsbook, while the total is set at 44.5 points. These conference rivals will meet for the first time since 2019.

Saints’ offense stalled in the second half in a loss to the Bengals

The New Orleans Saints (2-4, 2-4 ATS) had an opportunity to record back-to-back home wins after defeating the Seattle Seahawks in Week 5, but they fell short to the Cincinnati Bengals. New Orleans scored just six points in the second half and had a 26-21 lead with less than four minutes to go, but the visitors scored ten unanswered to celebrate a 30-26 victory.

Andy Dalton completed 17 of 32 passes for 162 yards and one touchdown. Tre’Quan Smith, who led the team with 43 receiving yards on three catches, scored that only passing TD. The Saints were dominant on the ground and had 228 yards on 34 carries. Rashid Shaheed exploded for a 44-yard touchdown, while Alvin Kamara needed just one yard to reach a 100-yard mark. Demario Davis was strong on defense as he registered game-high two sacks and team-high nine tackles.

QB Jameis Winston (back), QB Andy Dalton (back), WR Jarvis Landry (ankle), WR Michael Thomas (foot), CB Marshon Lattimore (foot), and TE Adam Trautman (ankle) are questionable to play on Thursday against Arizona.

Cardinals’ offense failed to score a TD in a loss to the Seahawks

The Arizona Cardinals (2-4, 3-3 ATS) lost the second game in a row; after losing to the Philadelphia Eagles at home, they lost 19-9 to the divisional foes Seattle Seahawks on the road. Arizona took a 3-0 lead early in the game and that was the only time the visitors were up as their offense failed to score a touchdown. The only TD was scored by the defense when Chris Banjo recovered a fumble in the end zone to make it 12-9 for the Seahawks. Seattle scored its lone TD in the fourth quarter to set the final score.

Kyler Murray completed 23 of 37 passes for 222 yards and an interception, but he did lead all the players with 100 rushing yards on ten carries. Zach Ertz and Marquise Brown combined for 138 yards on 12 receptions (19 targets). Arizona played well defensively and had five sacks. Zaven Collins recorded two of those sacks and led the Cards with nine tackles.

WR Marquise Brown is out with a left foot fracture, and he is expected to miss six weeks of action. QB Colt McCoy (calf), G Justin Pugh (knee), and CB Antonio Hamilton (foot) are also unavailable. K Matt Prater (hip), C Rodney Hudson (knee), and RB James Conner (ribs) are questionable to face the Saints on Thursday.


New Orleans:

  • 2-4 ATS in the last six games.


  • 7-3 ATS in the last ten games following an ATS loss
  • 15-5-1 ATS in the last 21 games in October

New Orleans Saints vs. Arizona Cardinals Pick  

Arizona lost wideout Marquise Brown for the next six weeks, approximately, but got DeAndre Hopkins back after he served his suspension. Hopkins is returning in a crucial moment for the Cardinals, who must get a win in this game, and I think he will be the most targeted player on Arizona’s offense. Kyler Murray will be glad to have him back, and a combination of Hopkins’ receiving abilities and Murray’s read option could be enough to beat the injury-troubled New Orleans. The Cardinals are not scoring plenty of points, but given the visitors have numerous offensive players inured or questionable for this Thursday tilt, I am backing the home side’s defense to prevail.

Pick: Take the Cardinals at -1.5 (-110)

The Total

Both Jameis Winston and Andy Dalton are banged up and whoever starts on Thursday, I don’t think will utilize the pass offense much. There’s no need for it when you have such runners as Alvin Kamara and Mark Ingram. Arizona’s offense is far from being impressive, especially in the last two weeks when they scored 26 points in total, so I don’t expect to see a high-scoring affair here. Under is 6-1 in the Saints’ last seven games following an ATS loss; Under is 5-0 in the Cardinals’ previous five games overall, while Under is 5-0 in Arizona’s last five vs. NFC rivals.

Pick: Go Under 46.5 points (-135)