The Los Angeles Angels take on the Chicago White Sox this Thursday afternoon to wrap up their three-game set at Guaranteed Rate Field in Chicago along with their seven-game regular-season series. We have prepared the best Angels vs. White Sox betting pick and odds, so let’s take a closer look.

Angels Sportsbook Betting Cash Bonuses

Overall Rating: 5/5
Read Review

Bookmaker sportsbook the #1 online sportsbook. In business for over 25yrs, provide safe legal online sports betting


100% Cash Bonus

The White Sox have dropped three of their first five encounters with the Angels in 2021 (Wednesday’s clash has been excluded), but they won last Tuesday’s opener at home, 9-3, playing as -265 favorites. Chicago is a strong fave once more, according to Bookmaker Sportsbook

The Angels continue to struggle at the dish          

The Los Angeles Angels fell to 70-74 on the season following that 9-3 defeat at the White Sox, recording their sixth loss in the last eight games overall. It was another poor offensive display, as the Angels had just six hits and failed to score more than three runs for the sixth time in the last 11 outings.

Los Angeles has scored only 33 runs through its first 11 games played in September. The Angels have smacked 13 homers and a paltry 12 extra-base hits in that span, while on the other side of the ball, they’ve registered a disappointing 4.74 ERA, 1.39 WHIP, and a .251 batting average against.

Shohei Ohtani was expected to get the starting call Thursday at Guaranteed Rate Field, but he’ll take the mound Friday against the Athletics. The Angels will opt for a bullpen day, and their relievers have posted a 4.46 ERA and 4.18 FIP in the last two weeks of action.

The White Sox hope to stay hot at home 

The Chicago White Sox haven’t been at their best lately, losing five of their previous ten games overall, but they’ve won six of their last seven contests at home. They improved to 83-61 on the season with that comfortable 9-3 victory over the Angels, retaining a huge 12.5-game lead ahead of the Cleveland Indians.

The White Sox will certainly win the AL Central for the first time since 2008. Over the last couple of weeks, they’ve slashed .274/.351/.412 while recording a 3.78 ERA, 1.20 WHIP, and a .226 batting average against.

Reynaldo Lopez will take the hill Thursday, and he’s 3-2 with a 2.05 ERA and 0.84 WHIP in six starts and ten relief appearances in 2021. The 27-year-old righty will get his third starting call this month, while Lopez has recorded a 2.63 ERA and 2.95 FIP over his previous six outings (24 innings).


LA Angels:

  • 2-6 in the last eight games overall
  • 2-6 in the last eight contests on the road 


  • 6-1 in the last seven games at home 

Los Angeles Angels vs. Chicago White Sox Pick

Although the White Sox haven’t impressed so far this month, they are playing in a much better form than the Angels, so I’m going with the hosts to win. Los Angeles has struggled at the plate for a while, and the visitors will have a tall task in this one, considering the White Sox’s pitching form.

Chicago’s relievers have posted the fifth-lowest ERA in the majors so far this month. Furthermore, the White Sox have scored 46 runs in their last seven outings at home. Their offense should make the difference in this one.

Pick: Take Chicago White Sox  

The Total:

The White Sox bullpen has had some ups and downs over the last two months, but in September, it has a sharp 2.89 ERA and 2.80 FIP. If Reynaldo Lopez put on a solid performance and his relievers continue to pitch well, this shouldn’t be a high-scoring affair.

As I’ve mentioned, the Angels cannot catch the right rhythm at the dish. Their 12 extra-base hits in September tell a lot about their form, so I’ll take the under on the totals. The hosts to win remain my best Angels vs White Sox betting pick.

Pick: Go under