An intriguing American League clash awaits us on Monday, June 27 at Angel Stadium of Anaheim with the first pitch set for 9:38 PM ET, so take a look at the best White Sox vs. Angels betting pick and odds.

Chicago and Los Angeles will open a three-game series in California, and the hosts are -135 moneyline favorites on BetOnline Sportsbook. These American League rivals have met four times this season and the series is tied at 2-2.

White Sox edged the Orioles to avoid the series sweep

The Chicago White Sox snapped a four-game losing streak with a 4-3 victory over the Baltimore Orioles and avoided the series sweep following Baltimore’s three wins. Still, the White Sox currently have a disappointing 34-37 record, and even though there are a lot of games to be played, they will have to improve if they want to be in the postseason.

Dylan Cease (6-3) displayed one of the best performances of his career as he allowed one run on four hits with 13 strikeouts and only one walk across 7.0 innings. Kendall Graveman got his 3rd save of the season, while Jose Abreu, Gavin Sheets, and Jos Harrison had two hits apiece with two RBIs and three runs combined.

Lucas Giolito (4-4) is getting the 13th start of the year when he takes on the Angels on Monday. The 27-year-old right-hander is struggling at the moment after suffering two consecutive losses with 7+ runs allowed in each. He has a disappointing 5.40 ERA, 1.56 WHIP, and 76/26 K/BB ratio in 63.1 innings. Giolito met the Angels once this season and took a loss as he registered a 4.50 ERA over 6.0 innings.

Angels escaped a series sweep with a win over the Mariners

The Los Angeles Angels improved to a 35-40 record following a narrow 2-1 victory over the Seattle Mariners at home. Seattle won the opening two games of the series, but Los Angeles managed to avoid a series sweep in a feisty affair that saw a big brawl and eight ejected players.

Reliever Andrew Wantz started the game for the Angels and got a couple of strikeouts in 1.0 innings, but Jose Suarez was the one to get a victory, his first of the season. Suarez pitched for 6.0 innings and allowed one run on five hits with eight strikeouts. Oliver Ortega recorded his first save of the campaign. On offense, Taylor Ward was the only Angel with a multi-hit game.

Noah Syndergaard (4-6) will take the mound for the 12th time this season. The 29-year-old right-hander carries a 3.86 ERA, 1.20 WHIP, and 40/15 K/BB ratio over 58.1 innings of work. Syndergaard didn’t face the White Sox since 2019.



  • 6-14 in the last 20 games against LA Angels
  • 1-4 in the last five games overall
  • 1-4 in the last five vs. American League West opponents

Los Angeles:

  • 5-1 in the last six games when playing at home against the White Sox
  • 9-4 in the last 13 vs. American League Central rivals

Chicago White Sox vs. Los Angeles Angels Pick  

Syndergaard lost in each of his four previous starts and he will be desperate to return to winning ways. He pitched well in two of those four losses but his offense let him down and even failed to get on the scoreboard. I don’t think that will happen against struggling Giolito because the Angels are batting .238 against righties and score 4.58 runs per nine innings. On the other hand, the White Sox are not batting well against right-handers – they are scoring just 3.66 runs per nine innings.

Pick: Take the Angels to win at -135

The Total

Although I am backing the Angels to torture Lucas Giolito in this one, I don’t expect a high-scoring affair because the Angels are not playing a lot of such games lately. The total has gone Under in 11 of LA Angels’ last 14 games, while the total went Under in seven of the Angels’ previous nine games against an opponent in the American League. When it comes to Chicago, the total has gone Under in four of the White Sox’s last five games.

Pick: Take Under 8.5 runs at -110