San Francisco takes on Arizona in a three-game NL West series finale at Chase Field in Phoenix, so here’s the best Giants vs. Diamondbacks betting pick along with the latest odds update on MyBookie Sportsbook

The Diamondbacks defeated the Giants 8-3 in Monday’s opener, while Tuesday’s clash has been excluded from this preview. San Francisco is a -140 road favorite for Wednesday’s closer, and the totals are listed at 8.5 runs. 

The Giants hope to break out of their slump                                      

The San Francisco Giants extended their losing streak to five games following Monday’s game at Chase Field. It was their 11th defeat in 14 games, and the Giants fell to 40-38 on the season, trailing the bottom wild card in the National League by two games. 

San Francisco has accounted for just 12 runs over its previous five outings, slashing an awful .196/.296/.307 across 163 at-bats. On the pitching side of things, the Giants have amassed a pedestrian 5.11 ERA, 1.36 WHIP, and .283 opposing batting average. 

Alex Cobb will get the ball Wednesday and search for his first win since May 17. The 34-year-old right-hander is 3-3 with a 4.59 ERA and 1.37 WHIP in 11 starts (51 innings) in 2022. Cobb has done a solid job since rejoining the Giants’ rotation on June 19 after a short stint on the IL, allowing five runs (two earned) on 11 hits across 13.1 innings of work (three starts). 

The D-backs beat the Giants to snap their two-game skid          

The Arizona Diamondbacks have been pretty inconsistent all season. They’ve lost nine of their previous 14 games overall but won four of their previous seven tilts. Madison Bumgarner posted a win against his former team last Monday, and the D-backs improved to 36-44 on the season. 

Arizona’s pitching staff has struggled a lot in the last couple of weeks, tallying a 5.18 ERA, 1.39 WHIP, and .253 batting average against through 97.1 innings pitched. At least, the Diamondbacks are hitting .260/.304/.486 with eight home runs across their last 173 at-bats. 

Merrill Kelly will toe the slab Wednesday, and the 33-year-old righty is 3-3 with a 3.21 ERA in ten career starts against the Giants. Kelly has been a solid option for the Diamondbacks so far this season, notching a 7-5 record with a 3.46 ERA and 1.26 WHIP in 16 starts and 91 frames of work. 


San Francisco: 

  • 10-3 in the last 13 road games against Arizona 


  • 4-8 in the last 12 games overall  
  • 3-14 in the last 17 games against the NL West   

San Francisco Giants vs. Arizona Diamondbacks Pick 

The Giants are too good to struggle for too long, and I’m backing them to right the ship against the Diamondbacks, whose pitching staff is a big problem. Merrill Kelly has allowed 12 runs over his last four starts, and the Diamondbacks’ bullpen holds a 5.20 ERA in the last ten days and 27.2 innings pitched. The current San Francisco lineup has 30 hits, six doubles, two triples, and three home runs in 115 at-bats against Kelly. 

On the other side, the Giants’ bullpen owns a 5.35 ERA in its last 33.2 frames of work, but their key relievers haven’t played a lot over the last seven days. I’m expecting them to make the difference down the stretch, as Alex Cobb is a wild card in this matchup and shouldn’t last for too long. 

Pick: Take San Francisco Giants at -140                                      

The Total:

The over is 6-2 in Arizona’s last eight games and 4-1 in its previous five outings at home. On the other side, four of the Giants’ last six games have produced eight or fewer runs in total.  

I lean toward the over in this game because I’m expecting the Giants to get things going at the dish and the Diamondbacks’ bullpen to continue with a shaky performance. Also, the starting duo is a questionable one. 

Pick: Go over 8.5 runs at +100