<p>The San Francisco 49ers will travel to face the Los Angeles Rams in a Week 5 game of the 2025 NFL season. The game will be held at SoFi Stadium in Inglewood, California. Kickoff is scheduled for Thursday night, October 2, 2025, at 8:15 PM, and it will be broadcast on AMZN.</p> <p>Both teams enter this game with a 3-1 record. The 49ers have been strong on the road with a 2-0 record away from Levi's Stadium. The Rams are undefeated at home, holding a 2-0 record at SoFi Stadium. Fans can expect clear skies and warm temperatures, although the dome setting means weather will not impact the game.</p> <h2>San Francisco 49ers Team Preview</h2> <p>The San Francisco 49ers have shown both strengths and weaknesses in their recent games. They won against the New Orleans Saints 26-21 and the Arizona Cardinals 16-15. However, they faced a setback against the Jacksonville Jaguars, losing 26-21.</p> <p>Christian McCaffrey is a key player for the 49ers, contributing significantly in rushing and receiving yards. In their last game, he managed 49 rushing yards and 6 receptions. Mac Jones and Brock Purdy have shared quarterback duties, both delivering over 560 passing yards in two games each.</p> <p>Injuries are a concern for the 49ers with several key players out. George Kittle, Trent Taylor, and Nick Bosa are among those on the injured reserve list. Brock Purdy and Ricky Pearsall are also out for their upcoming game against the Rams.</p> <h2>49ers vs Rams Game Day Info</h2> <ul><li>Sport: NFL</li><li>Teams: San Francisco 49ers vs. Los Angeles Rams</li><li>Venue: SoFi Stadium in Inglewood, CA</li><li>Date: Thursday, October 2, 2025</li><li>Betting Odds: 49ers +358, Rams -458</li></ul> <h2>Los Angeles Rams Team Preview</h2> <p>The Los Angeles Rams have had a strong start to the 2025 season. They won three of their first four games, with victories over the Colts, Titans, and Texans. Their only loss came against the Eagles in Week 3.</p> <p>Matthew Stafford is leading the offense with impressive numbers. He has thrown for 1,114 yards and eight touchdowns in four games. Puka Nacua is his top target, catching 42 passes for 503 yards.</p> <p>The Rams' defense has also been solid, ranking 7th in interceptions. Kam Curl has been a standout player, with two interceptions against the Colts. However, the team faces injury challenges, with key players like Ahkello Witherspoon out.</p> <h2>BTB Betting Pick</h2> <p>The 49ers are getting +8.5 points against the Rams. The Rams have a slightly better defense, ranking 16th in opponent score, while the 49ers rank 26th. However, the 49ers' offense ranks higher in passing yards. With the 49ers' strong passing game, they can cover the +8.5 spread. The projected score is Rams 24, 49ers 20.</p> <p>The total for the game is set at 43.5 points. The Rams and 49ers both have solid offenses, with the 49ers ranked 13th in scoring and the Rams 19th. Both defenses allow a fair amount of points, with the 49ers ranked 26th and the Rams 16th in opponent score. These factors suggest the game will go over the 43.5 total. The projected total score is 44 points.</p>

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