<p>The San Francisco 49ers will travel to Indianapolis to take on the Colts in a Week 16 game of the 2025 NFL season. The game will be held at Lucas Oil Stadium, featuring a retractable roof. Kickoff is set for Monday, December 22, 2025, at 8:15 PM and will be broadcast on ESPN.</p> <p>San Francisco comes into the game with a 10-4 record, showing strength on the road with a 6-2 mark. The Colts hold an 8-6 record, with a solid home performance of 6-1. The game odds favor the 49ers with a moneyline of -283, while the Colts are at +232. The spread is set at -6.5 for the 49ers and +6.5 for the Colts, with the total points over/under at 46.5.</p> <h2>San Francisco 49ers Team Preview</h2> <p>The San Francisco 49ers have had a strong season, winning four of their last five games. They beat the Tennessee Titans 37-24 in their most recent game. Brock Purdy had a great performance with 295 passing yards and three touchdowns.</p> <p>Christian McCaffrey has been a key player for the 49ers this season. He has rushed for 922 yards and scored nine touchdowns. He is also active in the passing game with 86 receptions and 820 receiving yards.</p> <p>The 49ers have some injury concerns as they head into their next game. Key players like Nick Bosa and Fred Warner are out for the rest of the season. Ricky Pearsall and Tatum Bethune are questionable for the upcoming game.</p> <h2>49ers vs Colts Game Day Info</h2> <ul><li>Sport: NFL</li><li>Teams: San Francisco 49ers vs. Indianapolis Colts</li><li>Venue: Lucas Oil Stadium in Indianapolis, IN USA</li><li>Date: Monday, December 22, 2025</li><li>Betting Odds: 49ers Moneyline -283, Colts Moneyline +232, 49ers Spread -6.5 (-107), Colts Spread +6.5 (-115), Total Over/Under 46.5 (-110)</li></ul> <h2>Indianapolis Colts Team Preview</h2> <p>The Indianapolis Colts have been facing challenges in recent weeks. They have lost their last five games, with the most recent being a close 18-16 loss to the Seattle Seahawks. The team struggled with passing, gaining only 118 yards, while their rushing attack managed 97 yards.</p> <p>Jonathan Taylor continues to be a key player for the Colts. He leads the team in rushing with 1,443 yards and has scored 16 touchdowns this season. However, the team faces difficulties due to injuries, with several players on the injured reserve list, including Daniel Jones and Anthony Richardson Sr.</p> <p>On defense, Zaire Franklin is a standout with consistent performances. Despite the team's struggles, he has been a reliable linebacker, recording multiple tackles in recent games. The defense will need to step up as they prepare for their next challenge at home.</p> <h2>BTB Betting Pick</h2> <p>The San Francisco 49ers are favored by 6.5 points against the Indianapolis Colts. The 49ers have a strong passing game, ranked 4th in the league. The Colts' defense struggles, ranked 29th in opponent offensive yards. The 49ers should cover the -6.5 spread.</p> <p>The total for the game is set at 46.5 points. The 49ers and Colts have allowed 436 and 427 points respectively this season. With both defenses giving up points, the total is likely to go over 46.5.</p>

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