<p>The San Francisco 49ers head to State Farm Stadium to play the Arizona Cardinals in Week 11 of the 2025 NFL season. The game will take place on Sunday, November 16, at 4:05 PM and will be broadcast on FOX. The weather forecast indicates a mild day with light rain, but the retractable roof might keep the field dry.</p> <p>The 49ers come into this game with a record of 6-4-0. They have been strong on the road with a 4-2-0 record. The Cardinals, on the other hand, hold a 3-6-0 record and have struggled at home, winning just one out of four games. Both teams are part of the NFC West division.</p> <h2>San Francisco 49ers Team Preview</h2> <p>The San Francisco 49ers have had mixed results in their recent games. They won against the New York Giants with a score of 34-24, showing strong offense with 159 rushing yards. However, they struggled against the Los Angeles Rams, losing 42-26 at Levi's Stadium.</p> <p>Mac Jones has been a key player for the 49ers. He passed for 319 yards and three touchdowns against the Rams. In the game against the Giants, he threw for 221 yards and two touchdowns.</p> <p>Christian McCaffrey is another important player for the team. He rushed for 106 yards and scored a touchdown in the win over the Giants. In the game against the Falcons, he ran for 129 yards and two touchdowns, highlighting his role in the team's offense.</p> <h2>49ers vs Cardinals Game Day Info</h2> <ul><li>Sport: NFL</li><li>Teams: San Francisco 49ers vs. Arizona Cardinals</li><li>Venue: State Farm Stadium in Glendale, AZ USA</li><li>Date: Sunday, November 16, 2025</li><li>Betting Odds: 49ers Moneyline -147, Cardinals Moneyline +123, 49ers Spread -2.5 (-115), Cardinals Spread +2.5 (-104), Total Over 48.5 (-110), Total Under 48.5 (-111)</li></ul> <h2>Arizona Cardinals Team Preview</h2> <p>The Arizona Cardinals have had a challenging season so far. They have lost four of their last five games, including a recent defeat to the Seattle Seahawks, 44-22. In that game, Jacoby Brissett threw for 258 yards and two touchdowns, but the defense struggled to contain the Seahawks' offense.</p> <p>Injuries have been a problem for the Cardinals this season. Key players like Kyler Murray and Zay Jones are on the injured reserve list. The team also has several other players listed as questionable for the upcoming games, which adds to the team's difficulties.</p> <p>Despite the challenges, some players have performed well. Trey McBride has been a consistent target, with 603 receiving yards and six touchdowns this season. Marvin Harrison Jr. is another standout with 525 receiving yards and four touchdowns. These players will be crucial as the Cardinals try to turn their season around.</p> <h2>BTB Betting Pick</h2> <p>The 49ers are favored by 2.5 points against the Cardinals. The 49ers have a strong passing game, ranking 4th in passing yards last season. The Cardinals' defense allowed 5823 yards, ranking 21st. Given these stats, the 49ers are likely to cover the spread. The projected score is 49ers 27, Cardinals 24.</p> <p>The total for this game is set at 48.5 points. Both teams have potent offenses, with the Cardinals scoring 400 points last season and the 49ers close behind at 389. Their defenses have also allowed a significant number of points. With these factors, the game is likely to go over the total. The projected total is 51 points.</p>

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