<p>The Louisville Cardinals, ranked #6, are set to take on the #22 Indiana Hoosiers at Gainbridge Fieldhouse in Indianapolis. This non-conference game will be held on a neutral site, with the Cardinals as the favorites. The game will be broadcasted on CBS at 2:15 PM ET on Saturday, December 6, 2025.</p> <p>Both teams come into this game with a strong 7-1 record for the season. Louisville has been strong at home with a 6-0 record, while Indiana has excelled with a 7-0 record at home. The spread for this game favors Louisville by 4.5 points. The over/under is set at 162.5 points. Fans can look forward to an exciting showdown between these two ranked teams.</p> <h2>Louisville Cardinals vs Indiana Hoosiers Game Day Info</h2> <ul><li>Sport: College Basketball</li><li>Teams: #6 Louisville Cardinals vs #22 Indiana Hoosiers</li><li>Venue: Gainbridge Fieldhouse, Indianapolis IN</li><li>Date: Saturday, December 6, 2025 at 2:15 PM ET</li><li>Betting Odds:         <ul><li>Louisville Spread: -4.5 (-112)</li><li>Indiana Spread: +4.5 (-112)</li><li>Louisville MoneyLine: -197</li><li>Indiana MoneyLine: +159</li><li>Over: 162.5 (-109)</li><li>Under: 162.5 (-117)</li></ul></li></ul> <h2>Louisville Cardinals Team Preview</h2> <p>The Louisville Cardinals have a strong offensive presence this season. They are averaging 94.6 points per game, ranking them 9th in the nation. Their three-point shooting is a key part of their offense, making 12.6 threes per game, which ranks 3rd nationally.</p> <p>On the road, the Cardinals hold a 1-1 record. Their only loss came against Arkansas, where they scored 80 points but allowed 89. Mikel Brown Jr. led the team in scoring with 22 points in that game.</p> <p>Ryan Conwell is a standout player for the Cardinals, averaging 19.5 points per game. He is shooting 41.9% from beyond the arc and contributes 4.9 rebounds per game. His performance will be crucial in upcoming games as the team seeks to maintain their strong start to the season.</p> <h2>Indiana Hoosiers Team Preview</h2> <p>Indiana Hoosiers are ranked #22 in the AP rankings. They have a strong start to the season with a record of 7-1. At home, they are undefeated with a 7-0 record, showing dominance on their court.</p> <p>The Hoosiers' offense is effective with a field goal percentage of 49.2%, ranking them 53rd. They average 86.4 points per game, which places them 61st nationally. Their three-point shooting is solid, making 10.2 per game, ranking them 46th.</p> <p>Key players for the Hoosiers include Tucker DeVries and Lamar Wilkerson. DeVries averages 16.8 points per game, and Wilkerson is close behind with 16.5 points. Tayton Conerway also contributes significantly with 12.6 points per game.</p> <h2>BTB Betting Pick</h2> <p>The spread for the game is set at Louisville -4.5. Louisville scores 94.6 points per game and allows fewer turnovers. Indiana scores 86.4 points per game and has fewer rebounds. Given Louisville's higher scoring and rebounding, picking Louisville to cover the -4.5 spread is reasonable. The projected score favors Louisville by more than 4.5 points.</p> <p>The over/under for the game is 162.5. Louisville averages 94.6 points, and Indiana averages 86.4 points per game. Combined, they score over 180 points on average. With both teams having strong offenses, the over 162.5 is a likely outcome.</p>

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