Hector Santiago (2-1, 3.58 ERA) and Mike Leake (0-3, 6.03 ERA) take the hill in the first of a three-game series between the Los Angeles Angels (13-18) and the St. Louis Cardinals (16-16) at Angel Stadium. Action begins at 10:05 p.m. ET on Tuesday, May. 10 and can be seen on FSMW and FSW.

Santiago pitched 5.1 innings in his last outing, surrendering three runs, striking out four and walking four in a 7-3 win over the Brewers. Mike Trout (.313, 16 Rs, 7 HRs, 23 RBIs, 2 SBs) went 1 for 3 Sunday. Leake went 5.0 innings, surrendering four runs, striking out three and walking one in a 5-4 win over the Phillies in his most recent start. Jeremy Hazelbaker (.297, 13 Rs, 6 HRs, 14 RBIs, 2 SBs) went 1 for 4 Sunday with one run, one home run, and one RBI.

The Angels are a small -120 favorite, but it's fair to wonder about the emotional state of the Angels. Garrett Richards and Andrew Heaney were both ruled out with significant injuries last week and now defensive stalwart Andrelton Simmons is out for a couple of months with thumb surgery. This will be the first interleague game of the season for the Cardinals, who are just 5-11 against teams .500 or better. They are 11-5 against teams with losing records, so the Angels fit the bill as a team that the Cardinals have had success against this season.

Pick - STL

Notes

When leading after seven innings, St. Louis is 10-7, while Los Angeles is 7-6.

The Cardinals managed to give up four walks in their last game. They'll have to pick it up against the Angels who are heading in with an 8-4 record against opponents who give up that many walks or more.

When they outhit their opponents, the Angels are 10-3. The Cardinals have a 13-3 record when outhitting opponents.

Ranking 24th in runs, Los Angeles has earned 110 this season. St. Louis ranks second with 175 runs.

Ranking 26th, Los Angeles is near the bottom of the league for its on-base plus slugging percentage (.674). St. Louis ranks in the top five at second with an OPS of .813.

When the Cardinals allow at least one home run, they are 8-12, well-matched with the Angels who are 9-15 when allowing at least one homer.