Matchup: Washington Nationals vs. San Francisco Giants

Date/Time: May 21st, 10:15 PM ET

Television: Local TV

MLB Betting Odds from WagerWeb

Probable Starters: Strasburg (Washington) vs. Cain (San Francisco)

Moneyline: Giants -110

Total: 6.5

The best pitching matchup of the day on Tuesday night will be played in the Bay Area, where the San Francisco Giants will go into MLB betting warfare against the Washington Nationals.

This West Coast swing for Washington has been a brutal disaster. The team is just 3-5 so far in its eight games played on the other side of the country, and the problems have been all over the diamond. The Nats have four games in which they have either been shut out or have scored just one run, and they now have allowed a total of 21 runs over the course of their last two games. They badly need a good effort on Tuesday out of RHP Stephen Strasburg to give this bullpen a bit of a rest after two very long days in a row. Of course, Strasburg hasn't been the stud of all studs this year, knowing that he has led his team to just a 3-6 record in his nine starts. He hasn't gotten any help, as the team is averaging just 2.7 runs per game for him, but even still, a 1.12 WHIP and a 2.83 ERA almost seem like they should be a tad better this early in the season for the righty.

The Giants are happy to be back at home after going 1-5 in their five games that were played on the road. They have now won 15 of their last 20 games played here at AT&T Park, and that's in spite of the fact that their pitching staff has been a horrid disappointing all season long. San Fran is going to be using RHP Matt Cain on Tuesday to counter Strasburg. The numbers for Cain really don't look good at this point in the season, as he is just 3-2 with a 5.43 ERA, and he has led his team to a 4-5 mark in those games. However, in his last three outings, Cain has looked a lot more like the Matt Cain we have known to grow and love. He picked up wins in all three of those games, though in the last of those games, he was rocked by the Colorado Rockies for six runs in 6.1 innings of work. Our big concern about Cain is the fact that he is still getting the ball up in the zone. He has allowed 13 home runs in his last six starts, and he only allowed 21 all of last season and has never allowed more than 22 in his career.

The 'over' is clearly the right play in this one, knowing that both teams just need to put three on the board to be able to get the job done for us. We just don't trust that Cain is going to be able to hold a Washington offense that has been screaming to have a bust out game down.

Washington Nationals @ San Francisco Giants Pick: Over 6.5