white sox indians mlb picksCorey Kluber (0-1, 2.49 ERA) takes the hill for the Cleveland Indians (5-8) as they square off against Jeff Samardzija (0-1, 4.29 ERA) and the Chicago White Sox (5-8) in the last of a three-game series at U.S. Cellular Field. The Indians won the last game 6-2 and the series is currently tied 1-1. Action begins at 2:10 p.m. ET on Wednesday, Apr. 22 and can be seen on STO, CSN-CHI and MLB Network.

Samardzija pitched 8.0 innings in his last outing, surrendering one run and striking out seven in a 2-1 defeat to the Tigers. Jose Abreu (.275, 6 Rs, 4 HRs, 9 RBIs) had another good game yesterday, going 2 for 4 with one run, one home run, and two RBIs. Against the White Sox, Kluber is 4-2 with a 3.09 ERA, 1.09 WHIP, and 59 strikeouts. Michael Brantley (.250, 2 Rs, 4 RBIs) has been successful at the plate to the start the season, going 2 for 4 yesterday with one run and one RBI.

Cleveland takes on Chicago as a -118 favorite. The Over/Under (O/U) for the matchup is sitting at seven runs. The White Sox have recorded an overall money line of -193 and have shown a weak performance as an underdog this season with a record of 2-6. Chicago has had a discouraging season against division opponents, earning records of 2-6 and 5-7 as the underdog and SU respectively. Opposing batters know they're in for a battle when they play Chicago. The White Sox are one of the top teams when it comes to pitching, allowing just 3.8 runs per home game.

In the other locker room, Cleveland is coming in with an overall money line of -549 and a disappointing record of 2-5as the favorite. They played poorly as the favorite over their last 10 games with a 1-5 record, and a 3-7 record SU. The The Indians allow just 4.2 runs per game, ranking them fifth in the AL. The Indians have established a reputation of overwhelming hitters with an AL-best 10.1 strikeouts per game.

The White Sox have a 5-4 record against right-handed starting pitchers on the year, which is what they'll be facing when Kluber takes the mound. Samardzija (RHP) will be on the hill against the Indians, who have a 3-3 record against right-handed starting pitchers.

Predictions: SU Winner - CWS, O/U - Over

Notes

The White Sox and Indians both hold losing records against teams in the AL Central. The White Sox sit at 5-8 in these matchups and the Indians have a 3-7 record.

The Indians are 0-1 when they go into extra innings.

The Indians are coming into this game after allowing zero walks during their last outing. The White Sox have a 1-2 record when opponents give up that many walks.

When they outhit their opponents, the Indians are 4-1. The White Sox have a 5-1 record when outhitting opponents.

Tied at 24th for total runs, Chicago and Cleveland have each notched 44 runs this season.

Ranking 27th, Chicago is near the bottom of the league in walks, notching 28 this season. Cleveland ranks in the top half at 15th with 38.

When the White Sox hit at least one home run, they are 4-4. When the Indians hit at least one homer, they have a 4-3 record.