Chris Sale (2-1, 5.32 ERA) and the Chicago White Sox (9-14) meet Alfredo Simon (4-1, 3.13 ERA) and the Detroit Tigers (17-10) in the second of a three-game division series at U.S. Cellular Field. The White Sox won the last game 5-2 and Chicago leads the series 1-0. The game gets underway at 8:10 p.m. ET on Wednesday, May. 6 and will air on FSN-DET and CSN-CHI+.

Sale is 6-5 with a 2.85 ERA against the Tigers in his career, but is up against a strong Detroit offense that's hitting .275 on the year. Jose Abreu (.270, 10 Rs, 5 HRs, 16 RBIs) went 1 for 3 yesterday with one run and one RBI. In his career against the White Sox, Simon is 1-0 with an 8.31 ERA, 2.08 WHIP, and four strikeouts. Anthony Gose (.313, 10 Rs, 1 HR, 7 RBIs, 5 SBs) has been hitting the ball well, going 2 for 4 yesterday with one run and one stolen base.

Chicago, a -144 favorite, will look to capitalize at home against Detroit. The Over/Under (O/U) for the matchup is set at seven runs. When playing as the favorite, the White Sox have a 4-4 record and overall money line at -692. Over the last 10 games, they have performed poorly when playing as the favorite (1-3).

Across the field, the Tigers have a nice record of 5-3 when they are the underdog and are +677 overall with the money line. Against teams in their division, they are 14-5 SU and have played well as the underdog with a 3-2 record. Detroit has stepped up their play against division opponents. They have averaged 5.3 runs per game, more than their season average of 4.5. Detroit is one of the top hitting teams in the AL with an average of 9.3 hits per contest. The Tigers have racked up 25 steals on the year, making them one of the most threatening base-running teams in the league. Switching gears to Detroit's pitching staff, they allow just 2.4 walks per game, second-best in the AL.

The White Sox will take on a right-hander (Simon) in this game. They have a 6-11 record against right-handed starting pitchers this season, but are 4-2 at home. The left-handed Sale will take the mound against the Tigers, who have a 5-2 record against lefty starters this season.

Predictions: SU Winner - DET, O/U - Under

Notes

The Tigers hold a 14-6 record in matchups against AL Central Division rivals, while the White Sox currently sit at 9-13 in these games.

When leading after 7 innings, Detroit is 9-4, while Chicago is 2-3.

The Tigers managed to give up five walks in their last game. They'll have to pick it up against the White Sox who are heading in with a 3-1 record against opponents who give up that many walks or more.

When they outhit their opponents, the White Sox are 6-1. The Tigers have a 15-2 record when outhitting opponents.

Ranking 30th, Chicago is at the bottom of the league in runs, scoring 75 this season. Detroit ranks in the top 10 at 10th with 119.

Ranking 28th, Chicago is near the bottom of the league in walks, notching 53 this season. Detroit ranks in the top 10 at eighth with 90.

When the White Sox hit at least one home run, they are 5-4. When the Tigers hit at least one homer, they have a 12-4 record.