Hector Noesi (0-3, 6.75 ERA) and the Chicago White Sox (10-15) go up against Jason Marquis (3-1, 5.22 ERA) and the Cincinnati Reds (14-14) in the first of a three-game interleague series at U.S. Cellular Field. The game gets underway at 8:10 p.m. ET on Friday, May. 8 and will air on FSN-OH and CSN-CHI.

In his most recent outing, Noesi pitched 4.1 innings, giving up five runs, striking out two and walking two in a 5-3 loss to the Twins. Jose Abreu (.278, 12 Rs, 5 HRs, 16 RBIs) went 1 for 3 yesterday. In his career against the White Sox, Marquis is 2-1 with a 9.00 ERA, 1.58 WHIP, and 17 strikeouts. Todd Frazier (.240, 21 Rs, 10 HRs, 19 RBIs, 3 SBs) has been doing well, going 2 for 3 yesterday with one run, one home run, and one RBI.

Chicago is favored by a small -108 margin in its matchup against Cincinnati. The teams combine to set the Over/Under (O/U) at nine runs. When playing as the favorite, the White Sox have a 6-5 record and overall money line at -607. They have an SU record of 10-15 against the NL and a 6-5 record when they were the favorite in those games.

Across the field, the Reds have a record of 7-8 when they are the underdog and are +151 overall with the money line. Against teams in the American League, they are 14-13 SU and 7-8 as the underdog. Cincinnati is one of the top home-run-hitting teams in the league with 38 home runs. The Reds have racked up 33 steals on the year, making them the most threatening base-running team in the league. The Reds are a problem for opposing batters, sporting a 3.60 ERA on the road this season. They also allow just 7.5 hits per game, good for tops in the NL.

This game will feature Marquis (RHP) on the mound against the White Sox, who have an 8-11 record when they take on a right-handed starter. The right-handed Noesi will take the mound against the Reds, who have an 11-10 record against righty starters this season.

Predictions: SU Winner - CIN, O/U - Under

Notes

When leading after 7 innings, Cincinnati is 5-5, while Chicago is 2-3.

Having scored one run in their last game, the White Sox are going to have to up their game if they want to win this matchup. The Reds have a 5-0 record in games where opponents scored that many runs or fewer.

When they are outhit, the White Sox are 2-14. The Reds have a 4-9 record when opponents outhit them.

Chicago ranks at the bottom of the league when it comes to home runs, hitting 14 this season. Cincinnati ranks in the top five at third with 38.

Ranking 11th, Cincinnati is in the top half of the league in hits, notching 7.85 per game. Chicago ranks in the top 10 at 10th with 8.25.

Ranking 26th, Chicago is near the bottom of the league for its on-base plus slugging percentage (.644). Cincinnati ranks in the bottom half at 18th with an OPS of .699.

The Reds are 9-12 in games where they allow one or more home runs. The White Sox are 5-11 when they allow at least one homer.