James Paxton (0-2, 5.08 ERA) and Ian Kennedy (2-1, 5.03 ERA) take the hill in the first of a two-game series between the Seattle Mariners (14-17) and the San Diego Padres (17-16) at Safeco Field. Action begins at 10:10 p.m. ET on Tuesday, May. 12 and can be seen on FSN-SD and ROOT-NW.

Paxton pitched 7.0 innings in his most recent start, surrendering two runs, striking out four and walking three in a 5-4 defeat to the Angels. Nelson Cruz (.344, 21 Rs, 14 HRs, 27 RBIs, 1 SB) went 1 for 4 Sunday with one run. Kennedy went 7.0 innings, surrendering one run and striking out five in a 9-1 win over the Giants in his last outing. Justin Upton (.294, 23 Rs, 8 HRs, 24 RBIs, 7 SBs) has been successful at the plate for the Padres, going 2 for 4 Sunday.

The odds for Seattle and San Diego are even, while the Over/Under (O/U) is currently unavailable. In interleague play, the Mariners have a 0-3 record SU. Seattle's pitchers fall apart when National League teams are on the field. Its average runs allowed per game rises to 5.7 against NL teams, compared to its 4.4 season average. Opponents have consistently been struck out by the Mariners, who lead the AL in strikeouts per home game with 9.5.

San Diego is 0-3 SU against American League opponents. Offensively, the Padres have really sputtered in interleague games. They have decreased their season average of 4.6 runs per game by averaging 3.0 in those contests. The Padres have a dynamic offense, ranking fourth in the league with 101 extra base hits. The Padres allow 4.5 runs per game, but does worse whenever an AL opponent is on the schedule. They bring that runs allowed average up to 10.0 against teams from the AL.

The Mariners have an 11-12 record against right-handed starting pitchers on the year, which is what they'll be facing when Kennedy takes the mound. Paxton (LHP) will be on the hill against the Padres, who have a very good 6-3 record against left-handed starting pitchers.

Predictions: SU Winner - SD

Notes

The Padres lost their last game by a one-run margin. In games decided by one run, the Mariners are 8-7. The Padres are 5-5 in close games this season.

When the Mariners play into extra innings, they have a 3-3 record. The Padres are 1-2 when their games exceed nine innings.

Having scored one run in their last game, the Padres are going to have to up their game if they want to win this matchup. The Mariners have a 5-0 record in games where opponents scored that many runs or fewer.

When they outhit their opponents, the Mariners are 6-6. The Padres have a 13-2 record when outhitting opponents.

Ranking 25th in runs, Seattle has earned 117 this season. San Diego ranks fourth with 153 runs.

Ranking 23rd, Seattle is near the bottom of the league in walks, notching 81 this season. San Diego ranks in the bottom half at 19th with 86.

When the Mariners hit at least one home run, they are 11-9. When the Padres hit at least one homer, they have an 11-6 record.