Brett Oberholtzer (0-0, 0.00 ERA) and the Houston Astros (20-13) go up against Tim Hudson (1-3, 4.50 ERA) and the San Francisco Giants (17-16) in the second of a two-game interleague series at Minute Maid Park. The Giants won the last game 8-1 and San Francisco leads the series 1-0. The game gets underway at 8:10 p.m. ET on Wednesday, May. 13 and will air on CSN-BAY ROOT-SW.

This is the first start of the season for Oberholtzer. He pitched 143.2 innings last season, finishing 5-13 with a 4.39 ERA, 1.38 WHIP, and 94 strikeoutsJake Marisnick (.316, 15 Rs, 3 HRs, 13 RBIs, 9 SBs) went 1 for 4 yesterday. In his pitching opportunities against the Astros, Hudson is 5-0 with a 1.24 ERA. He meets a less-than-stellar Houston offense that's batting just .224. Matt Duffy (.300, 4 Rs, 1 HR, 15 RBIs) has been hitting the ball well, going 3 for 4 yesterday with five RBIs.

Houston, a -117 favorite, will look to capitalize at home against San Francisco. The Over/Under (O/U) for the matchup is eight runs. When playing as the favorite, the Astros have a 5-6 record and overall money line at +870. They are 1-3 as the favorite over their last 10 games. The Astros seem to play better on offense against opponents from the NL, putting up an average of 10.0 runs per game, well over their season average of 4.4. The Astros are a power hitting team with 46 home runs, one of the highest totals in the MLB. The Astros are a nightmare for opponents on the bases with 36 steals, one of the highest totals in baseball. Turning to the pitching staff, the Astros rank third in the NL in ERA with a 3.45 team average. The Astros lead the league in WHIP at 1.11.

Switching gears, the Giants come into this game with a win percentage of .571 when playing as the underdog (8-6) and an overall money line of -171. Over the past 10 matchups, they are 7-3 SU and have an unblemished 1-0 record when they were an underdog to win. San Francisco has stepped up their play against AL opponents averaging an impressive 4.3 runs per game compared to their 3.2 runs per game season average. San Francisco's pitching staff tends to perform well when they play AL opponents. They've allowed an average of 2.0 runs per game against teams from the AL lower than their season average of 3.9.

The only other game between the two teams went San Francisco's way. The Astros will take on a right-hander (Hudson) in this game and have an 11-8 record against right-handed starting pitchers this season. The left-handed Oberholtzer will take the mound against the Giants. Against lefty starters this season, they've racked up an impressive 6-2 record.

Predictions: SU Winner - HOU, O/U - Over

Notes

Houston recorded at least two errors for the sixth time this season.

The Astros are 3-0 in games that go into extra innings. Meanwhile, the Giants are 3-1 in such matchups.

The Giants are coming into this game after allowing zero walks during their last outing. The Astros have a 0-2 record when opponents give up that many walks.

When they are outhit, the Giants are 3-10. The Astros have a 6-8 record when opponents outhit them.

San Francisco ranks near the bottom of the league at 27th when it comes to home runs, hitting 20 this season. Houston ranks in the top five at second with 46.

Ranking 13th, Houston is in the top half of the league in hits, notching 7.69 per game. San Francisco ranks in the top 10 at sixth with 8.81.

Houston and San Francisco both rank in the bottom half of the league for their on-base plus slugging percentage. Houston sits at 17th with an OPS of .700 and San Francisco ranks 19th with an OPS of .695.

The Giants are 6-10 in games where they allow one or more home runs. The Astros are 7-7 when they allow at least one homer.