Hector Santiago (2-2, 2.57 ERA) is on the hill for the Los Angeles Angels (16-17) as they square off against Jordan Lyles (2-3, 4.42 ERA) and the Colorado Rockies (11-18) in the second of a two-game series at Angel Stadium. The Rockies lost the last game 5-2, continuing a 10-game losing streak. Action begins at 10:05 p.m. ET on Wednesday, May. 13 and can be seen on ROOT-RM and FSN-W.

Santiago pitched 6.1 innings in his last outing, surrendering zero runs, striking out five and walking four in a 3-2 defeat to the Astros. Kole Calhoun (.310, 14 Rs, 3 HRs, 18 RBIs, 1 SB) continued his strong play yesterday, going 3 for 4. Lyles is 2-1 with a 5.82 ERA against the Angels in his career. He takes on a below-average Los Angeles offense that's batting just .230. Corey Dickerson (.313, 15 Rs, 5 HRs, 16 RBIs) has been successful at the plate for the Rockies, going 2 for 3 yesterday with one RBI.

Los Angeles is a -151 favorite against Colorado and the Over/Under (O/U) for this game is sitting at eight runs. The Angels have an overall money line of -405 and a record as the favorite of 11-10. In interleague play, they have a 0-3 record SU. The Angels have seen a decline in scoring against teams in the NL, averaging 2.0 runs per game. They average 3.7 runs per game on the season. Los Angeles's pitchers fall apart when National League teams are on the field. Its average runs allowed per game rises to 4.3 against NL teams, compared to its 3.8 season average. The Angels are the fifth-best team in the AL at limiting walks to their opponents, allowing only 2.8 walks per game so far this season.

In games where it is the underdog, Colorado has a 8-10 record and an overall money line of -614. They played poorly as the underdog over their last 10 games with a 1-7 record, and a 1-9 record SU. The Rockies allow 5.7 runs per game, but have damaged those numbers in the past 10 games, allowing 8.0 runs per game during that span.

The Angels have the edge in the season series, 1-0. The Angels have a 9-14 record against right-handed starting pitchers on the year, which is what they'll be facing when Lyles takes the mound.

Predictions: SU Winner - LAA, O/U - Over

Notes

When leading after 7 innings, Los Angeles is 7-6, while Colorado is 3-5.

The Angels are coming into this game after allowing one walk during their last outing. The Rockies have a 3-10 record when opponents give up that many walks or fewer.

The Angels are coming into the game with two consecutive wins, while the Rockies currently have a losing streak of 10.

When they outhit their opponents, the Angels are 9-6. The Rockies have a 10-3 record when outhitting opponents.

Both falling near the bottom of the league based on total runs this season, Los Angeles ranks 26th with 123 runs and Colorado is 27th with 115.

Ranking 30th, Colorado is at the bottom of the league in walks, notching 59 this season. Los Angeles ranks near the bottom at 23rd with 84.

The Angels are 10-10 in games where they hit one or more home runs. The Rockies are 8-9 when they hit at least one homer.