Jason Marquis (3-3, 6.63 ERA) and the Cincinnati Reds (18-21) are in Kansas City to go up against Jeremy Guthrie (3-2, 5.44 ERA) and the Royals (25-14) in a matchup that has the potential for plenty of offense. This is the second of a two-game series at Kauffman Stadium. The Royals won the last game 3-0 and Kansas City leads the series 1-0. The game gets underway at 8:10 p.m. ET on Wednesday, May. 20 and will air on FSN-OH and FSN-KC.

Guthrie has a 5.06 ERA and a 1-1 record in his career against the Reds, but is up against a struggling Cincinnati offense that's hitting just .238 on the year. Eric Hosmer (.322, 26 Rs, 7 HRs, 29 RBIs, 2 SBs) went 1 for 4 yesterday with one run. In his career against the Royals, Marquis is 3-0 with a 4.50 ERA. He gets a strong Kansas City offense that's batting .287. Todd Frazier (.250, 26 Rs, 12 HRs, 23 RBIs, 6 SBs) went 1 for 4 yesterday.

Kansas City is a -138 favorite in this game and the Over/Under (O/U) is set at eight runs. The Royals are 12-9 as the favorite and have an overall money line of +942. They have performed well against the National League to earn an SU record of 24-14 and a 12-9 record when they were the favorite. The Royals have one of the most prolific offenses in the entire AL, averaging 5.0 runs per game. The Royals rank third in the majors in extra base hits with 128. Don't expect the Kansas City hitters to swing wildly. They average an AL-low 5.6 strikeouts per game. Kansas City's pitching staff can be considered for best in its league, with an NL-low 3.38 team ERA. The Royals don't give up many hits to opposing batters, ranking second in the AL with only 7.6 hits allowed per game.

Across the field, the Reds have a subpar record of 8-13 when they are the underdog and are -197 overall with the money line. Over the past 10 matchups, they are 4-6 SU and have played poorly as the underdog with a 1-4 record. Cincinnati has stepped up their play against interleague opponents averaging an impressive 5.0 runs per game compared to their 4.0 runs per game season average. The Reds are known for their power, smashing 48 home runs. Cincinnati is a terror on the base paths, with an MLB-best 43 stolen bases. Playing competition from the AL really brings the worst out of the Cincinnati pitchers. They allow 5.3 runs per game against teams in the AL, which is higher than their season average of 4.5.

So far this season, the Royals are 1-0 against the Reds. This game will feature Marquis (RHP) on the mound against the Royals, who have a 14-9 record when they take on a right-handed starter. The right-handed Guthrie will take the mound against the Reds, who have a 14-14 record against righty starters this season.

Predictions: SU Winner - KC, O/U - Over

Notes

Kansas City won its last game in a shutout, its second of the season. Cincinnati has been shut out three times this season.

When the Royals play into extra innings, they have a 3-0 record. The Reds are 1-3 when their games exceed nine innings.

Having scored zero runs in their last game, the Reds are going to have to up their game if they want to win this matchup. The Royals have a 2-0 record in games where opponents scored that many runs.

When they are outhit, the Royals are 1-9. The Reds have a 5-16 record when opponents outhit them.

Ranking 24th in home runs, Kansas City has hit 29 this season. Cincinnati ranks fourth with 48 home runs.

Kansas City ranks at the top of the league when it comes to hits with 10.05 per game this season. Cincinnati ranks in the top half at 12th with 8.03.

Ranking 16th, Cincinnati is in the bottom half of the league for its on-base plus slugging percentage (.705). Kansas City ranks in the top five at second with an OPS of .772.

When the Reds allow at least one home run, they are 10-17. When the Royals allow one or more homers, they have a 12-9 record.