Kyle Hendricks (0-1, 5.15 ERA) and the Chicago Cubs (22-17) are in San Diego to meet Odrisamer Despaigne (2-2, 6.75 ERA) and the Padres (20-21) in a matchup that has the potential for plenty of offense. This is the last of a three-game series at Petco Park. The Cubs won the last game 3-2 and the series is currently tied 1-1. The game starts at 9:10 p.m. ET on Thursday, May. 21 and will air on FSN-SD, CSN-CHI+ and MLB Net.

In his most recent outing, Despaigne pitched 3.0 innings, allowing seven runs, striking out one and walking two in a 10-0 loss to the Nationals. Justin Upton (.284, 30 Rs, 11 HRs, 29 RBIs, 8 SBs) went 1 for 4 yesterday with one run, one home run, and two RBIs. In his career against the Padres, Hendricks is 1-0 with a 1.38 ERA, 0.85 WHIP, and 13 strikeouts. Kris Bryant (.291, 20 Rs, 4 HRs, 25 RBIs, 4 SBs) went 1 for 3 yesterday with one run, one RBI, and one stolen base.

San Diego is a small -112 favorite in this game and the Over/Under (O/U) is set at seven runs. The Padres perform well as a favorite with a 12-6 record, but haven't fared as well with the overall money line (-80). They have SU record of 5-5 and are unbeaten as the favorite (3-0) over their last 10 games. The have been extremely effective at striking opposing batters out, averaging 8.6 strikeouts per game.

Switching gears, the Cubs come into this game with a win percentage of .500 when playing as the underdog (8-8) and an overall money line of +171. Over the past 10 matchups, they are 6-4 SU and have a poor 0-2 record when they were an underdog to win. The Cubs rank second in the NL in road scoring, averaging five runs per game. Chicago is a terror on the base paths, ranking second in the MLB with 39 stolen bases. Switching gears to Chicago's pitching staff, they allow just 2.8 walks per road game, fourth-best in the NL. The Chicago pitching staff has been an intimidating group on the road this year, averaging 8.1 strikeouts per game.

The Padres are 3-2 against the Cubs this season. This game will feature Hendricks (RHP) on the mound against the Padres, who have a 14-16 record when they take on a right-handed starter. Taking the hill against the Cubs will be the right-hander Despaigne. They sport a 17-14 record against righties.

Predictions: SU Winner - SD, O/U - Over


In their last game, the Cubs won by a margin of one run. The Padres are 6-6 in one-run games. The Cubs have a 12-7 record in close games.

The Cubs are 5-1 in games that go into extra innings. Meanwhile, the Padres are 1-2 in such matchups.

The Cubs managed to give up four walks in their last game. They'll have to pick it up against the Padres who are heading in with an 8-4 record against opponents who give up that many walks or more.

When they outhit their opponents, the Cubs are 11-3. The Padres have a 14-3 record when outhitting opponents.

Ranking 15th, Chicago sits in the top half of the league in runs, scoring 166 this season. San Diego ranks in the top 10 at ninth with 181.

Ranking 19th, San Diego is in the bottom half of the league in walks, notching 109 this season. Chicago ranks in the top five at second with 145.

When the Padres hit at least one home run, they are 13-8, well-matched with the Cubs who are 15-6 when hitting one or more homers.