Zack Greinke (5-1, 1.52 ERA) and the Los Angeles Dodgers (24-16) square off against Andrew Cashner (1-7, 3.24 ERA) and the San Diego Padres (20-22) in a game that has the potential to be low scoring. This is the first of a three-game series at Dodger Stadium. Action begins at 10:10 p.m. ET on Friday, May. 22 and can be seen on FSN-SD and SportsNet LA.

Greinke is 5-0 with a 1.58 ERA, 0.75 WHIP, and 55 strikeouts against the Padres. Adrian Gonzalez (.345, 29 Rs, 9 HRs, 32 RBIs) went 1 for 3 yesterday. Cashner is 1-4 with a 2.22 ERA against the Dodgers in his career. He is up against a quality Los Angeles offense that's batting .261. Justin Upton (.285, 30 Rs, 11 HRs, 29 RBIs, 9 SBs) went 1 for 3 yesterday with one stolen base.

Los Angeles is a -167 favorite against San Diego and the Over/Under (O/U) for this game is sitting at six runs. The Dodgers have an overall money line of +61 and a record as the favorite of 22-15. Los Angeles has had an impressive season against division opponents, earning 17-12 and 17-13 records as the favorite and SU respectively. The Dodgers have seen a decline in scoring as of late, averaging 3.2 runs during the last 10 games compared to their season average of 4.7 runs per game. The Dodgers have no trouble scoring as they rank second in the NL in offense with 4.7 runs per game. The Dodgers are one of the best in the NL in terms of hits at home with an impressive 9.1 per game. Los Angeles leads the whole NL in walks, earning an average of 4.0 per game. Crossing over to the pitching staff, the Dodgers are the fourth-best team in the league at limiting hits and walks to their opponents, recording a WHIP of 1.16 so far this season. Opponents have consistently been struck out by the Dodgers, who lead the NL in strikeouts per game with 9.1.

In the other locker room, San Diego is coming in with an overall money line of -216 and a disappointing record of 8-14 as the underdog. They played poorly as the underdog over their last 10 games with a 2-5 record, and a 4-6 record SU. The Padres average 4.8 runs allowed per game, but does better whenever another team from the NL West is on the schedule. They bring that runs allowed average down to 4.0 against division foes.

The Dodgers lead the season series, 4-2. The Dodgers have a great 16-3 record at home (22-12 overall) against right-handed starting pitchers, which is what they'll be facing when Cashner takes the mound. Greinke (RHP) will be on the hill against the Padres, who have a 14-16 record against right-handed starting pitchers.

Predictions: SU Winner - LAD, O/U - Over

Notes

The Dodgers are 17-13 against their divisional rivals, while the Padres are 15-12 against their division.

When the Dodgers play into extra innings, they have a 2-2 record. The Padres are 1-2 when their games exceed nine innings.

Having scored zero runs in their last game, the Padres are going to have to up their game if they want to win this matchup. The Dodgers have a 5-0 record in games where opponents scored that many runs.

When they outhit their opponents, the Padres are 14-3. The Dodgers have an 18-3 record when outhitting opponents.

Los Angeles and San Diego both rank in the top 10 of the league in runs. Los Angeles sits at sixth with 186 runs this season and San Diego ranks 10th with 181.

Ranking first in walks, Los Angeles has earned 160 this season. San Diego ranks 19th with 109 walks.

When the Dodgers hit at least one home run, they are 20-8, well-matched with the Padres who are 13-8 when hitting one or more homers.