Jered Weaver (3-4, 4.37 ERA) and the Los Angeles Angels (22-22) meet Tyson Ross (2-4, 3.93 ERA) and the San Diego Padres (21-24) in the first of a three-game interleague series at Angel Stadium. The game starts at 9:05 p.m. ET on Monday, May. 25 and will air on FSN-SD and FSN-W.

In his last start, Weaver pitched 7.0 innings, giving up three runs, striking out four and walking three in a 4-3 victory over the Blue Jays. Mike Trout (.301, 34 Rs, 11 HRs, 25 RBIs, 8 SBs) went 1 for 4 yesterday with one RBI. In his career against the Angels, Ross is 1-1 with a 1.78 ERA. He meets a struggling Los Angeles offense that's batting just .231. Justin Upton (.284, 32 Rs, 12 HRs, 35 RBIs, 9 SBs) has been hitting the ball well for the Padres, going 2 for 4 yesterday with two runs, one home run, and six RBIs.

Los Angeles, a -140 favorite, will look to capitalize at home against San Diego. The Over/Under (O/U) for the matchup is seven runs. The Angels are 13-12 as the favorite and have an overall money line of -191. They have a winless record (0-2) in games played as the favorite during their last 10 games. The Angels seem to play worse on offense against National League opponents. In those matchups, Los Angeles has only averaged 2.6 runs per game compared to its 3.8 season average. In games against National League opponents, Los Angeles's pitchers are doing better against opposing batters. It only gives up an average of 3.2 runs per game, well under their season average of 3.9. The Angels don't give up many hits to opposing batters, ranking third in the AL with only 7.9 hits allowed per game.

Switching gears, the Padres come into this game with a weak win percentage of .320 when playing as the underdog (8-17) and an overall money line of -516. They have played poorly as the underdog as of late. They managed a 1-6 record when playing as the underdog and an SU record of 3-7. The Padres will be looking to pick it up in this one after recent offensive struggles. In their 10 most recent games, San Diego's run production has dropped to 2.5 runs per game, compared to 3.8 for the duration of the season. San Diego's pitching staff tends to perform poorly when they play AL opponents. They've allowed an average of 8.6 runs per game against teams from the AL, higher than their season average of 4.6.

The Angels will take on a right-hander (Ross) in this game and have a 15-18 record against right-handed starting pitchers this season. The right-handed Weaver will take the mound against the Padres, who have a 14-19 record against righty starters this season.

Predictions: SU Winner - LAA, O/U - Over


San Diego has won 55% (12-10) of its games when leading after 7 innings. However, Los Angeles has won 57% (12-9) of its games when taking a late lead.

Having scored one run in their last game, the Angels are going to have to up their game if they want to win this matchup. The Padres have a 4-1 record in games where opponents scored that many runs or fewer.

When they are outhit, the Padres are 3-19. The Angels have a 5-16 record when opponents outhit them.

Los Angeles and San Diego both rank in the bottom half of the league in home runs. Los Angeles sits at 16th with 40 home runs this season and San Diego ranks 17th with 39.

Los Angeles and San Diego both rank in the top half of the league in hits. Los Angeles sits at 14th with 7.63 hits per game and San Diego ranks 11th with 8.25.

Ranking 30th, Los Angeles is at the bottom of the league for its on-base plus slugging percentage (.649). San Diego ranks near the bottom at 23rd with an OPS of .687.

The Padres are 13-19 in games where they allow one or more home runs. The Angels are 10-19 when they allow at least one homer.