Jose Quintana (2-6, 4.28 ERA) and Vincent Velasquez (0-0, 0.00 ERA) start in the last of a three-game series between the Chicago White Sox (27-30) and the Houston Astros (34-26) at U.S. Cellular Field. The Astros lost the last game 4-2, continuing a six-game losing streak. Action begins at 8:10 p.m. ET on Wednesday, Jun. 10 and can be seen on ROOT-SW and WPWR.

Quintana is 1-1 with a 3.14 ERA in his appearances against the Astros, and goes up against a below-average Houston offense which is batting just .234 this season. Jose Abreu (.279, 30 Rs, 10 HRs, 35 RBIs) continued his strong play yesterday, going 2 for 4 with two runs, one home run, and two RBIs. This is the first time Quintana will take the hill this season. George Springer (.235, 27 Rs, 8 HRs, 19 RBIs, 12 SBs) went 1 for 5 yesterday.

Chicago is a -140 favorite against Houston and the Over/Under (O/U) for this game is sitting at eight runs. The White Sox have an overall money line of -483 and a record as the favorite of 15-12. Opponents have consistently been struck out by the White Sox, who rank fourth in the AL in strikeouts per game with 8.2.

In games where it is the underdog, Houston has a 19-13 record and an overall money line of +639. They have been on a bit of a dry streak over their last 10 games. They managed a 0-4 record when playing as the underdog. Offensively, the Astros have really sputtered in the last 10 games. They have decreased their season average of 4.1 runs per game by averaging 2.9 during that stretch. The Astros can change the game with one swing of the bat, leading the league with 79 home runs. The Astros are an excellent base stealing team with 49 stolen bases, ranking third in the MLB. Houston's pitching staff is one of the top in the AL, with a 3.54 ERA. When it comes to preventing batters from getting on base, the Astros are the best in the league with a WHIP of 1.16 for the season.

The White Sox lead the season series, 4-1. The White Sox have a 22-24 record against right-handed starting pitchers on the year, which is what they'll be facing when Velasquez takes the mound. Quintana (LHP) will be on the hill against the Astros, who have a 12-12 record against left-handed starting pitchers.

Predictions: SU Winner - HOU, O/U - Over

Notes

The total has gone UNDER in 8 of Houston's last 11 games.

Houston is 0-5 SU in its last 5 games.

Houston is 0-5 SU in its last 5 games on the road.

The total has gone UNDER in 4 of Houston's last 5 games when playing Chi White Sox.

Houston is 1-4 SU in their last 5 games when playing Chi White Sox.

Houston is 1-6 SU in their last 7 games when playing on the road against Chi White Sox.

The total has gone UNDER in 6 of Houston's last 7 games when playing on the road against Chi White Sox.

When the White Sox play into extra innings, they have a 4-2 record. The Astros are 3-2 when their games exceed nine innings.

The Astros managed to give up four walks in their last game. They'll have to pick it up against the White Sox who are heading in with a 10-4 record against opponents who give up that many walks or more.

When they are outhit, the White Sox are 6-25. The Astros have a 9-17 record when opponents outhit them.

Houston tops the league in home runs with 79 this season. Chicago ranks near the bottom at 28th with 40.

Chicago and Houston both rank in the top half of the league in hits. Chicago sits at 11th with 8.23 hits per game and Houston ranks 15th with 7.75.

Ranking 29th, Chicago is near the bottom of the league for its on-base plus slugging percentage (.648). Houston ranks in the top half at 14th with an OPS of .711.

The Astros are 12-18 when they allow at least one home run. The White Sox perform similarly when they allow one or more homers with a 14-23 record.