In the second of a two-game series between the St. Louis Cardinals (51-25) and the Chicago White Sox (51-25) at Busch Stadium, John Lackey (6-4, 3.35 ERA) and Jose Quintana (3-7, 3.95 ERA) get the ball. The White Sox won the last game 2-1 and Chicago leads the series 1-0. The game starts at 8:15 p.m. ET on Wednesday, Jul. 1 and will air on CSN-CHI and FSN-MW.

Lackey is 3-6 with a 3.81 ERA against the White Sox in his career, and faces a less-than-stellar Chicago offense that's hitting just .240 on the year. In his career against the Cardinals, Quintana is 1-0 with a 1.69 ERA, 1.88 WHIP, and four strikeouts. Jose Abreu (.293, 43 Rs, 13 HRs, 42 RBIs) has been doing well offensively for the White Sox, going 2 for 5 yesterday with one RBI.

St. Louis is a -155 favorite in this game and the Over/Under (O/U) is seven runs. The Cardinals perform well as a favorite with a 42-14 record and have an overall money line of +2,334. Over the last 10 games, they have a very good record when playing as the favorite (8-2). The most recent 10-game stretch for the Cardinals has gone great. Over that span, St. Louis is averaging 5.5 runs per game, well over their season average of 4.1. The Cardinals rank fourth in the NL in hits with 9.0 per game. As for the pitching staff, the Cardinals lead the AL in ERA with a 2.61 team average. The Cardinals are second in the NL in hits allowed with just 8.2 per game.

Switching gears, the White Sox come into this game with a weak win percentage of .325 when playing as the underdog (13-27) and an overall money line of -1,283. Over the past 10 matchups, they are 4-6 SU and have played poorly as the underdog with a 1-4 record.

So far this season, the White Sox are 1-0 against the Cardinals. The Cardinals will take on a left-hander (Quintana) in this game and have a 7-9 record against left-handed starting pitchers this season. Taking the hill against the White Sox will be the right-hander Lackey. They sport a 27-32 record against righties.

Predictions: SU Winner - STL, O/U - Over

Notes

In their last game, the White Sox won by a margin of one run. The Cardinals are 16-12 in one-run games. The White Sox have a 15-14 record in close games.

The White Sox are 7-2 in games that go into extra innings. Meanwhile, the Cardinals are 6-4 in such matchups.

The White Sox are coming into this game after allowing two walks during their last outing. The Cardinals have a 21-9 record when opponents give up that many walks or fewer.

When they outhit their opponents, the White Sox are 24-6. The Cardinals have a 35-8 record when outhitting opponents.

Ranking 30th in runs, Chicago has earned 259 this season. St. Louis ranks 18th with 310 runs.

Ranking 29th, Chicago is near the bottom of the league in walks, notching 172 this season. St. Louis ranks in the top half at 11th with 234.

The Cardinals are 31-11 in games where they hit one or more home runs. The White Sox are 19-20 when they hit at least one homer.