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San Francisco got 3 passing strikes from Alex Smith en route to a 45-3 victory over Buffalo on Sunday in Week 5 action at Candlestick Park.
Bettors who backed the 49ers were also rewarded, as they covered the closing number as a favorite of 10 at sportsbooks. Over-Under bettors saw the total score go OVER the closing total of 45.5.
Frank Gore rushed for 106 yards, while Kendall Hunter added 81 yards in the win. Michael Crabtree and Vernon Davis added 113 and 106 receiving yards respectively.
Brad Smith rushed for 35 yards for Buffalo, while Fred Jackson added 29 yards. Ryan Fitzpatrick threw for 126 yards for the Bills, while receivers Scott Chandler and Stevie Johnson had 40 and 39 yards respectively.
San Francisco outgained Buffalo 621-204 yards in the game, while the battle of first downs was won 29-10 by the 49ers.
The time of possession battle favored San Francisco as their offense was on the field for 36:17, longer than the 23:43 of their opponents.
San Francisco looks to continue their winning ways next game with a battle against the Giants. The Bills will aim to get back on the winning track at Arizona.