Washington and Baltimore close down their two-game interleague series at Oriole Park at Camden Yards on Wednesday, June 22, 2022, so we bring you the best Nationals vs. Orioles betting pick and odds. 

Tuesday’s opener is excluded from the analysis, while the Orioles open as slight -125 home favorites for Wednesday’s closer. The Nationals sit at +115 moneyline odds, and the totals are listed at 9.5 runs on BetOnline Sportsbook.  

The Nats hold the worst record in the National League                                      

The Washington Nationals entered the Orioles series carrying a 24-46 record. They were sitting bottom of the National League, and the Nats have dropped 11 of their previous 14 games overall. Last Sunday, Washington put an end to its eight-game losing streak with a 9-3 thrashing of the Philadelphia Phillies. 

The Nationals’ pitching staff has been a disaster all season. It owns a pedestrian 5.42 ERA in June. Patrick Corbin will get the starting call Wednesday in Baltimore, and the 32-year-old left-hander is 3-9 with a terrible 6.59 ERA and 1.78 WHIP in 14 starts (69.2 innings) in 2022. 

After grabbing a couple of wins in his first two starts in June, Corbin was charged for a loss in a heavy 10-1 defeat to Philadelphia this past Thursday. He was obliterated for nine runs (two earned) on eight hits across just 3.1 frames of work.  

The O’s sit bottom of the crowded AL East         

The Baltimore Orioles are the worst team in the AL East, but they are far away from the worst team in the American League. The O’s were sitting at 30-38 following a 2-1 victory to the Tampa Bay Rays this past Sunday. It was their sixth win in nine games. 

The Orioles have gone 9-8 through their first 17 outings in the month of June, compiling an underwhelming 4.71 ERA, 1.45 WHIP, and .287 batting average against. Tyler Wells will get the nod Wednesday, and the 27-year-old right-hander has been a bright spot in Baltimore’s rotation as of late. 

Wells is 4-4 with a 3.62 ERA and 1.07 WHIP in 13 starts (59.2 innings) this season. He’s gone 3-0 in his previous four starts, surrendering only six earned runs on 14 hits across 22 frames of work. Last Thursday, Tyler fired six innings of a one-run ball in a 10-2 dismantling of the Toronto Blue Jays. 



  • 3-11 in the last 14 games overall   
  • 4-9 in the last 13 games on the road     


  • 6-3 in the last nine games overall 
  • 4-1 in the last five home games against Washington  
  • 5-1 in Tyler Wells’ last six starts 

Washington Nationals vs. Baltimore Orioles Pick 

Frankly, this game could easily go either way, and I’m more interested in the totals. Going with the Orioles seems a reasonable bet given Patrick Corbin’s form and the Nationals’ struggles on the mound. 

Neither team has impressed at the plate in the last seven days, but I’m expecting a high-scoring affair because of their pitching. The Nats have recorded a .670 OPS over their previous six contests, while the Orioles have posted a .664 OPS in their last five tilts. 

Pick: Take Baltimore Orioles at -125                                

The Total:

Patrick Corbin has allowed a whopping 23 runs (16 earned) on 36 hits over his previous four starts and 19.2 innings of work. The current Orioles are slashing .272/.302/.462 in 44 at-bats against Corbin, so I would be surprised if the Nationals’ lefty keeps Baltimore quiet in this duel. On the other side, the current Nats are 4-for-4 against Tyler Wells, as Josh Bell, Nelson Cruz, Yadiel Hernandez, and Juan Soto all have one hit versus the Orioles’ righty. 

Keep your eyes on Josh Bell, who’s hitting .284/.383/.657 with seven home runs across 67 at-bats in June. The Orioles’ bullpen has a 4.04 ERA and 3.32 FIP in the last ten days, while the Nats’ relievers have registered a 4.53 ERA and 7.09 FIP in that span. 

Pick: Go over 9.5 runs at -110