USC Trojans vs Oregon Ducks Betting Pick & Prediction for 11/22

College Football Preview

In Week 13 of the 2025 NCAA football season, the USC Trojans travel to face the Oregon Ducks. This game will take place at Autzen Stadium in Eugene, Oregon, on Saturday, November 22, at 3:30 PM. Fans can catch the action live on CBS.

The Trojans, ranked 16th in both the AP and Coaches Polls, hold an 8-2 record. They are 2-2 on the road this season. On the other side, the Ducks come in with a 9-1 record and rank 6th in the AP Poll and 5th in the Coaches Poll. They have won five of their six home games this season.

USC Team Preview

The USC Trojans have shown strong performance in recent games. They secured a 26-21 win against the Iowa Hawkeyes at home. In this game, the Trojans recorded 254 passing yards and 109 rushing yards.

Earlier, the Trojans defeated the Northwestern Wildcats with a 38-17 score. Their offense was effective, achieving 309 passing yards and 174 rushing yards. They also maintained possession well with 24 first downs.

USC has had success on the road, winning against the Nebraska Cornhuskers 21-17. Their ground game was solid with 214 rushing yards. The Trojans’ defense also played well, recovering four fumbles during the game.

USC vs Oregon Game Day Info

  • Sport: NCAA Football
  • Teams: USC Trojans vs. Oregon Ducks
  • Venue: Autzen Stadium in Eugene, OR
  • Date: Saturday, November 22, 2025
  • Betting Odds: USC +297, Oregon -384, USC Spread +10.0 (-108), Oregon Spread -10.0 (-111), Total Over 59.5 (-112), Total Under 59.5 (-108)

Oregon Team Preview

The Oregon Ducks have been strong at home this season. They recently defeated the Minnesota Golden Gophers 42-13 at Autzen Stadium. In that game, the Ducks gained 331 passing yards and 179 rushing yards.

Dante Moore has been a key player for the Ducks this season. He has thrown for 2,190 yards and 21 touchdowns in 10 games. This performance has placed him first on the team for passing yards and touchdowns.

On the ground, the Ducks have two standout running backs. Noah Whittington has rushed for 623 yards and scored 5 touchdowns. Jordon Davison has added 461 rushing yards and 12 touchdowns, leading the team in rushing touchdowns.

BTB Betting Pick

The USC Trojans are set to cover the +10.0 spread against the Oregon Ducks. USC’s offense ranks 13th in points for, while Oregon’s defense ranks 55th in points against. With a projected score of Oregon 35, USC 27, the Trojans have the potential to stay within the spread.

For the over/under, the recommendation is to go with the over 59.5. Both teams have strong offenses, with Oregon scoring 390 points and USC scoring 382 points this season. The projected total score of 62 points suggests that the over is a reasonable pick.