The NCAAF season continues with Week 6, and among many intriguing games scheduled for Saturday, October8, we’re covering this Big 12 tilt, so feel free to check out the best Horned Frogs vs. Jayhawks betting pick and odds.

Both TCU and Kansas are looking to maintain their perfect records when they meet at David Booth Kansas Memorial Stadium. The Horned Frogs are 7-point favorites on BetOnline Sportsbook, while the total is set at 67.5 points. These conference foes met once in 2021, and TCU won that game 31-28 in Fort Worth. 

Horned Frogs destroyed the Sooners at home

The TCU Horned Frogs (4-0, 4-0 ATS) recorded their first conference win of the campaign in a 55-24 demolition job of the Oklahoma Sooners at home. For the second time this year, TCU scored 55+ points, while they covered a +5 spread with ease. The Horned Frogs totaled 668 yards opposite Oklahoma’s 355 and had seven first downs more than the Sooners (29-22). 

Max Duggan completed 23 of 33 passes for 302 yards, three touchdowns, and no interceptions. He added 116 rushing yards and two touchdowns on just five carries. Kendre Miller led all the runners with 136 yards and a couple of scores on 13 attempts, while Taye Barber led all the receivers with 107 yards and a touchdown on three receptions. Dee Winters had two sacks, while Johnny Hodges recorded ten total tackles as he led his defense in this win. 

WR Quincy Brown is bothered by an unknown injury, and it has yet to be determined how long he will be out. QB Chandler Morris has missed the last three games with a left knee injury, and it is uncertain if it will keep him out of the lineup versus Kansas on Saturday.

Jayhawks edged the Cyclones at home

The Kansas Jayhawks (5-0, 5-0 ATS) continued with excellent displays and recorded another victory. This time around, the Jayhawks beat the Iowa State Cyclones 14-11 at home and covered a +3.5 spread along the way. Kansas scored all of its 14 points in the space of six minutes in the second quarter. The visitors were better in total yards (313-213), first downs (20-10) and possession (35:02-24:51), but the hosts wanted this win more and got it. 

Jalon Daniels completed 7 of 14 passes for 93 yards, no touchdowns, and no interceptions. The pass offense didn’t work here, but run offense was solid as the Jayhawks collected 112 yards and two touchdowns on 31 carries. Devin Neal led all the runners with 75 yards on 12 attempts, while Luke Grimm caught four passes for 46 yards. Defensively, Kansas had five sacks opposite Iowa State’s one.  Ra’Mello Dotson and Rich Miller led the team with seven tackles apiece. 


  • 2-6 ATS in the last eight conference games
  • 1-4 ATS in the last five road games vs. a team with a winning home record


  • 8-0 ATS in the last eight games overall
  • 6-0 ATS in the last six games following an ATS win
  • 5-0 ATS in the last five conference games
  • 4-0 ATS in the last four home games

TCU Horned Frogs vs. Kansas Jayhawks Pick  

Both teams have been impressive this season and are among 16 unbeaten in college football at the moment. It’s going to be a tight encounter that could go either way, but given the spread, I am going with the Jayhawks, like I did last week against the Cyclones. TCU has the 4th best offense in the country that averages 48.5 ppg, but I think the Jayhawks, who allow 16.0 ppg on average at home, will contain the visitors. One team will remain undefeated following this game, and I am not saying it’s going to be Kansas, but I believe they can cover.

Pick: Take the Jayhawks at +7.5 (-120)

The Total

TCU and Kansas are combining for almost 89 points per game and around 500 passing yards per game, which means we could have a classic shootout and a high-scoring affair. I am pretty sure they will combine for around 60 points here, but I am going with Kansas’ defense to slow down TCU’s high-flying offense. That’s why I am not brave enough to bet on Over 67.5 points. Only one of the last ten H2H duels produced more than 67.5 points. Under is 5-2 in the Jayhawks’ last seven home games, while Under is 5-1 in Kansas’ previous six vs. a team with a winning record.Pick: Go Under 67.5 points (-110)