The 2022 Stanley Cup continues Wednesday, May 25, with Game 5 of the Western Conference Semifinals between St. Louis and Colorado, so we have prepared the best Blues vs. Avalanche betting pick and odds. 

After a 6-3 thrashing of the Blues in Game 4 at Enterprise Center in St. Louis, the Avalanche are one win away from the conference finals. Colorado is a heavy -255 home fave for Wednesday’s battle at Ball Arena in Denver, while the Blues are listed as +215 moneyline underdogs with a total of 6.5 goals on BetDSI Sportsbook

The Blues are in dire straits                          

The St. Louis Blues lost Jordan Binnington at the start of Game 3, and with Ville Husso in the crease, they didn’t stand a chance against the Avalanche. Husso yielded four goals on just 23 shots, and the Blues suffered a 5-2 defeat in front of the home fans. 

St. Louis completely fell apart in Game 4, taking just 20 shots toward Colorado’s goalie. They blew a 1-0 lead, while Ville Husso surrendered five goals on 36 shots, including four in the second period. The Blues went 2-for-3 with the man advantage, and David Perron led the way with a couple of goals. 

Perron has accounted for nine goals and four assists so far this postseason, while Ryan O’Reilly has added seven goals and five dishes. Husso is 1-4 with a terrible 3.76 GAA and .884 save percentage in five appearances in the 2022 Stanley Cup. 

The Avs dominated the Blues in Game 4            

The Colorado Avalanche took full advantage of Jordan Binnington’s absence. After scoring five goals on just 27 shots in Game 3, the Avs netted six goals on 37 shots in Game 4 and fully deserved to grab a huge win away from home. 

Colorado erased a 1-0 deficit last Monday, tallying four goals through the first eight minutes of the second period. Nazem Kadri went off for a hat trick and an assist, Mikko Rantanen scored once, while defensemen Bowen Byram and Valeri Nichushkin accounted for two assists apiece. 

Darcy Kuemper will guard the cage Wednesday, aiming for his third consecutive victory. The 32-year-old goalie has allowed ten goals over the previous four meetings with the Blues. He’s 5-1 with a 2.14 GAA and .917 save percentage this postseason. 


St. Louis: 

  • 2-7 in the last nine road games against Colorado 


  • 5-1 in the last six games against St. Louis 
  • 7-1 in the last eight games overall 
  • 10-3 in the last 13 games at home 

St. Louis Blues vs. Colorado Avalanche Pick 

I was all over the Avs in Game 4, and I’m expecting them to finish the job in five games. However, the moneyline odds are not attractive, so give me the Avalanche to beat the puckline at +100. Colorado’s offense has played very well over the last few weeks, while the Blues’ defense hasn’t looked good without Jordan Binnington in the crease. 

Binnington’s absence is a massive blow for the Blues. Also, defensemen Torey Krug and Marco Scandella are both on the shelf as well, so I don’t trust the Blues’ blue line. 

Pick: Take Colorado Avalanche -1.5 at +100            

The Total:

The first two games of the series in Colorado have produced five goals in the total each. After a couple of low-scoring affairs, we saw seven goals in Game 3 and nine in Game 4 in St. Louis. The Avs’ offense is building up its form, while the Blues’ injury-depleted defense is in big trouble. 

Eight of the last ten meetings between the Blues and Avalanche have gone over the total. Also, the over is 9-3 in Colorado’s last 12 games played in May, and it is 12-6 in St. Louis’ previous 18 contests against the Western Conference. 

Pick: Go over 6.5 goals at -110