The Week 2 of the NFL is providing us a lot of exciting matchups and divisional duels on Sunday, September 18, including this NFC West encounter, so make sure you check out the best Seahawks vs. 49ers betting pick and odds.

Seattle and San Francisco are going into Week 2 in different moods when they meet at Levi’s Stadium. The 49ers are -9.5 favorites on BetOnline Sportsbook, while the total is set at 41.5 points. These NFC West rivals have faced twice last year, and the Seahawks won both games.

Seahawks surprised ineffective Broncos

The Seattle Seahawks were -6.5 home underdogs in the opening game of the new NFL season, but they defended the home turf and beat the Denver Broncos and former QB Russell Wilson 17-16. It was a great defensive display from the Seahawks, combined with Denver’s bad decisions in crucial offensive possessions, and even though Seattle had more luck than brains, they got away with a W.

Seattle was inferior in total yards (253-433), but forced two fumbles in the end zone and recovered both, while Denver’s kicker Brandon McManus missed a 64-yard FG attempt in the final 20 seconds of the tilt. Geno Smith was quite effective as he completed 23 of 28 attempts for 195 yards and two touchdowns. Colby Parkinson and Will Dissly were on the receiving end of those TD passes, while Rashaad Penny had 60 rushing yards on 12 carries. Jordyn Brooks and Cody Barton combined for 22 tackles and one sack.

49ers succumbed to a disappointing defeat in Chicago

The San Francisco 49ers displayed a weak performance in a 19-10 road defeat to the Chicago Bears, even though they were 6-point favorites. Frisco had a 10-0 lead midway through the third quarter, but their offense stopped since and Chicago scored 19 unanswered to book a W. The Niners were better in total yards (331-204), but that didn’t help them.

Trey Lance was awful in this one; he completed just 13 of 28 pass attempts for 164 yards, no touchdowns, and one interception. Lance did lead the team in rushing yards with 54 on 13 carries, while Deebo Samuel scored the lone (rushing) TD for the 49ers. Talanoa Hufanga had a strong defensive outing with 11 total tackles (two for a loss), and one pass defended.

Tight end George Kittle sat out the last game with a groin injury, and it is undetermined if he will take the field on Sunday against the Seahawks.



  • 5-2 ATS in the last seven games overall
  • 12-5 ATS in the last 17 games as a road underdog

San Francisco:

  • 8-24-1 ATS in the last 33 games as a home favorite

Seattle Seahawks vs. San Francisco 49ers Pick  

I do expect the Niners to show a much better display in front of home fans and bounce back from a devastating defeat to Chicago. Still, I am not sure how they will fare against the Seahawks, who are 15-5-1 ATS in the last 21 H2H meetings and 7-3 ATS in the previous ten H2H duels in San Francisco. Seattle was lucky to beat Denver, and I don’t think luck will be on their side again on Sunday, but I believe the Seahawks can stay close and cover.

Pick: Take the Seahawks at +10.5 (-130)

The Total

I am not sure about these two offenses because they didn’t look good in Week 1. Although the 49ers should improve and score more than 10 points they had in Chicago, I don’t expect to see them erupt offensively in this one. A better defense will win this game, so I am backing a low-scoring affair. Under is 8-2 in the Seahawks’ last ten games as an underdog; Under is 4-0 in the 49ers’ previous four games overall, while Under is 4-0 in San Francisco’s last four vs. NFC rivals.

Pick: Go Under 41.5 points (-110)