The NFL playoffs start with this NFC Wild Card game in Santa Clara on Saturday, January 14, and here you can read the best Seahawks vs. 49ers betting pick and odds.

San Francisco is searching for the 11th consecutive win when they welcome Seattle at Levi’s Stadium. The 49ers are -9.5 favorites on BookMaker Sportsbook, while the total is set at 42.5 points. These divisional foes met twice this season, and the 49ers won both games.

Seahawks entered playoffs thanks to Green Bay’s loss

The Seattle Seahawks (9-8-0, 7-10-0 ATS) bizarrely secured their playoff spot. Not only that they needed to beat the Los Angeles Rams, but they also needed the Green Bay Packers to lose to the Detroit Lions at home. The Seahawks forced overtime through Jason Myers’ field goal with a bit more than two minutes to go and even had a chance to win in regulation, but Myers’ FG attempt hit the right post. Still, he made amends in overtime with his fourth field goal of the game which gave the Seahawks a 19-16 victory. The Packers played later that night and needed a win to reach the postseason, but the Lions made an upset at Lambeau Field and sent Seattle to the playoffs.

Geno Smith completed 19 of 31 passes for 213 yards, one touchdown, and two interceptions in a win over the Rams. He also added 51 rushing yards on four carries. Kenneth Walker III was the most productive player on the ground with a game-high 114 yards on 29 attempts. Tyler Lockett caught that lone TD pass from Smith as he finished with 54 yards on four receptions. Colby Parkinson and DK Metcalf combined for 87 yards on five catches. Defensively, Seattle had five sacks while Cody Barton led the team with seven tackles.

WR Marquise Goodwin (shoulder), TE Will Dissly (knee), and RB Rashaad Penny (fibula) are out indefinitely. S Ryan Neal (knee) and G Phil Haynes (ankle) are questionable to face San Francisco on Saturday.

49ers easily defeated the Cardinals at home

The San Francisco 49ers (13-4-0, 11-6-0 ATS) recorded their 10th consecutive win with a 38-13 rout of the Arizona Cardinals at home. The Niners shut the visitors down in the second half and allowed zero points, while they scored a season-high 38 on the other end. The hosts were excellent defensively as they forced four turnovers and committed none on the other end.

Brock Purdy completed 15 of 20 passes for 178 yards and three touchdowns. George Kittle was on the receiving end of two of those TD passes, while Christian McCaffrey also scored a receiving touchdown. Elijah Mitchell had only five carries in the game, but two of them were for touchdowns. Brandon Aiyuk led the 49ers in receiving yards with 59 on four receptions. On defense, Tashaun Gipson Sr. registered a pair of interceptions, while Azeez Al-Shaair had a game-high ten tackles.

QB Jimmy Garoppolo (foot), QB Trey Lance (ankle), and WR Jordan Matthews (knee) are out indefinitely. LB Dre Greenlaw (back) and CB Ambry Thomas (ankle) are questionable to play on Saturday against the Seahawks.



  • 1-7 ATS in the last eight games overall
  • 0-5 ATS in the last five vs. NFC rivals
  • 1-5 ATS in the last six games following an ATS loss

San Francisco:

  • 21-8 ATS in the last 29 games overall
  • 5-1 ATS in the last six playoff games
  • 5-0 ATS in the last five home games
  • 8-0 ATS in the last eight vs. NFC West opponents

Seattle Seahawks vs. San Francisco 49ers Pick

The Niners are the hottest team in the NFL right now, and although the Seahawks were one of the most pleasant surprises this year, I think it will be the end of the road for them on Saturday. San Francisco has the league’s best defense that allows 16.3 points per game and it already limited the Seahawks to just 20 points in two H2Hs this year. The 49ers kept the opponents to 20 or fewer points in nine of their last ten games, and I am backing them to do it again. San Francisco averages 26.5 points per contest – the 6th best offense in the league.

Pick: Take the 49ers at -8.5 (-120)

The Total

Although both H2H duels this season were low-scoring, the 49ers are currently in excellent form when it comes to offense. They scored 33+ points in five of the last six games, failing to do it only against Seattle in a 21-13 victory. This time around, though, I am backing the hosts to go 30+, even though it’s a playoff game and we could expect strong defense from the visitors. The Seahawks are allowing 23.6 points per game, so it’s clear they cannot rely on their defense. Over is 4-1 in the Seahawks’ last five playoff games, while Over is 5-1 in the 49ers’ previous six games overall.

Pick: Go Over 40.5 points (-130)