Plenty of NFL games in Week 4 will be tight and rather unpredictable, and this NFC tilt on Sunday, October 2, is one of them, so you can’t afford to miss out on the best Seahawks vs. Lions betting pick and odds.

Seattle and Detroit enter Week 4 with a 1-2 record and both will hope to return to .500 when they meet at Ford Field. The Lions are 4-point favorites on Bovada Sportsbook, while the total is set at 48 points. These NFC rivals have faced once in 2021, and the Seahawks won that game 51-29 in Seattle.

Seahawks fell short to the Falcons after a poor second half

The Seattle Seahawks had a nice opportunity to improve to a 2-1 record when they welcomed the Atlanta Falcons last week. Seattle had a 20-17 lead at halftime but scored just three points in the second half in a 27-23 loss. Jason Myers’ field goal with a bit over three minutes remaining put the Seahawks up by three, but Atalanta scored a winning touchdown with only 35 seconds to go.

Geno Smith completed 32 of 44 passes for 325 yards, two touchdowns, and one interception. Seattle’s dynamic wideout duo of Tyler Lockett and DK Metcalf combined for 140 yards and a touchdown on 14 receptions (23 targets). Will Dissly also found the end zone, while on the ground, Rashaad Penny was solid with 66 yards on 14 rush attempts. Jordyn Brooks led the team on defense with nine total tackles.

T Shelby Harris (personal) and WR Marquise Goodwin (knee) are questionable to feature against Detroit on Sunday.

Lions dropped a double-digit lead in a loss to the Vikings

The Detroit Lions were on a brink of a surprising road win over divisional foes Minnesota Vikings, but even though they had a 10-point lead midway through the fourth quarter, the Lions failed to win. It was 24-14 for Detroit until 7:50 to go, while Minnesota completed a comeback to make it 28-24 with 45 seconds on the game clock.

Jared Goff completed 25 of 41 passes for 277 yards, one touchdown, and one interception. Jamaal Williams was a presence on the ground with 87 yards and two touchdowns on 20 carries. In the air, T.J. Hockenson scored the lone passing TD, while Josh Reynolds and Amon-Ra St. Brown combined for 169 yards on 12 catches (19 targets). Alex Anzalone was the only Lion with 10+ total tackles as he registered 11.

WR DJ Chark Jr. (ankle), G Jonah Jackson (finger), WR Josh Reynolds (ankle), and LB Chris Board (knee) are questionable to face the Seahawks on Sunday, while D’Andre Swift (ankle) is out indefinitely.



  • 4-2 ATS in the last six games against Detroit
  • 4-1 ATS in the last five games in October


  • 4-15-1 SU in the last 20 games
  • 0-5 SU in the last five games played in October

Seattle Seahawks vs. Detroit Lions Pick  

This game will likely be a one-possession and although I am leaning toward the Lions when it comes to the straight-up win, I will go with the Seahawks to cover. Even Seattle’s low-scoring offense that averages 15.7 ppg can hurt Detroit’s secondary and defense that allows the league-high 31.0 ppg. Geno Smith, although clumsy and inadequate at times, started developing good chemistry with Tyler Lockett and DK Metcalf, who combined for nearly 350 yards in three games. The Seahawks’ run offense is not strong enough, so they will be relying on a pass offense and solid secondary that surrendered only three passing TDs in three games.

Pick: Take the Seahawks at +4 (-110)

The Total

While Seattle’s secondary is a better part of its defense, the run defense is the second-worst in the NFL with 157.0 yards per contest allowed to the opponents. With D’Andre Swift out, Jamaal Williams will get a bunch of touches from the backfield, and he could get to 100+ rushing yards in this one. Detroit does have the second-best offense in the league that is averaging 31.7 ppg, so I expect to see a high-scoring affair here. Over is 4-1 in the Seahawks’ last five vs. NFC rivals; Over is 5-0 in the Lions’ previous five games overall, while Over is 5-0 in Detroit’s last five vs. NFC opponents.

Pick: Go Over 47.5 points (-120)