Another divisional rivalry game will be played in Week 8 of the NFL on Sunday, October 30, and here you can get the best 49ers vs. Rams betting pick and odds.

San Francisco is looking to avoid the third straight loss when they take on Los Angeles at SoFi Stadium. The 49ers are slight -1.5 favorites on BetDSI Sportsbook, while the total is set at 43 points. These divisional rivals have met twice in 2021, and the home side was better each time.

49ers were dismantled by the Chiefs at home

The San Francisco 49ers (3-4-0, 3-4-0 ATS) are playing in a hot and cold form this season, and at the moment, they are cold as ice. The Niners first lost to the Atlanta Falcons on the road and then suffered a massive 44-23 home defeat to the Kansas City Chiefs. It was a season-high 44 points allowed by the team that is labeled as one of the contenders for the Super Bowl, which is far from being ideal. The good thing for Frisco is that the NFC West is wide open and they still have enough time to recover and finish ahead of Seattle, Los Angeles, and Arizona.

Jimmy Garoppolo completed 25 of 37 passes for two touchdowns and one interception. George Kittle led the Niners in receiving yards with 98 on six catches with a touchdown. Brandon Aiyuk was also busy on offense with seven receptions for 82 yards, while Ray-Ray McCloud III had 65 yards with a score on four receptions. Christian McCaffrey was handed his debut after his trade from the Carolina Panthers. CMC ended with 62 scrimmage yards on ten touches. On defense, Charvarius Ward led the team with ten tackles.

FB Kyle Juszczyk (finger), QB Trey Lance (ankle), and RB Tyrion Davis-Price (ankle) are out and will not play on Sunday against the Rams. DT Arik Armstead (foot), WR Deebo Samuel (hamstring), and LB Dre Greenlaw (calf) are questionable.

Rams snapped a two-game losing skid

The Los Angeles Rams (3-3-0, 2-4-0 ATS) bounced back from a couple of losses to the 49ers and Cowboys, in which they scored just 19 points in total. They managed to beat the Carolina Panthers 24-10 at home, allowing a season-low ten points along the way. The Rams didn’t allow the Panthers to score in the second half and dominated in total yards (360-203), first downs (22-8), and possession (37:05-22:55).

Matthew Stafford completed 26 of 33 passes for 253 yards, one touchdown, and one interception. Allen Robinson II was on the receiving end of that TD pass as he chipped in 63 yards on five catches. Cooper Kupp, as usual, led the Rams with 80 yards on seven receptions, while Darrell Henderson Jr. and Ben Skowronek scored a rushing touchdown apiece. Defensively, Ernest Jones and Bobby Wagner each recorded seven tackles.

C Brian Allen Allen is sidelined after undergoing a procedure on his knee, and he is not likely to return until the beginning of November. RB Cam Akers is out as he is seeking out a trade destination, and it is unclear when he will return to action.


San Francisco:

  • 5-11 ATS in the last 16 games after allowing more than 250 yards passing in their previous game

Los Angeles:

  • 11-4-1 ATS in the last 16 games following a bye week
  • 4-0 ATS in the last four games after allowing less than 250 total yards in their previous game

San Francisco 49ers vs. Los Angeles Rams Pick  

The Niners now have one of the most exciting and complete running backs in football – Christian McCaffrey, but he will need a couple of weeks to learn a playbook before starting to post 100-yard displays from scrimmage. The Rams are coming off a bye week, which is not a good sign for the 49ers, who lost the last two games. Considering they beat Los Angeles a couple of weeks ago in the first H2H of the season, I expect the hosts to get a W this time around. The offense of the reigning champions is surprisingly bad and low-scoring this year, and although I don’t expect them to erupt on Sunday, I do back their defense to stop the Niners and prevail.

Pick: Take the Rams at -0.5 (+100)

The Total

I mentioned the Rams’ inefficient offense, which is one of the worst in the NFL. It averages 17.3 points per game, and its run offense is non-existent, only the Buccaneers have a worse run offense at the moment. San Francisco is a bit better in both offense and defense, but we can’t say the 49ers are a high-scoring team that relies on offense. It’s going to be a tight battle with no more than 44 points. Under is 5-1 in the last six H2H meetings; Under is 12-3 in the 49ers’ previous 15 games overall, while Under is 4-0 in the Rams’ last four games overall.

Pick: Go Under 44.5 points (-135)