The 2022 NFC Championship Game is set for Sunday, January 30, with the kick-off at 6:30 PM ET, so we bring you the best 49ers vs. Rams betting pick along with the latest team news, stats, and betting odds. 

San Francisco squares off against Los Angeles for the third time this season. The 49ers aim for their seventh consecutive victory over the Rams, opening as 3.5-point road underdogs with a total of 45.5 points on MyBookie Sportsbook.

The Niners upset the Packers in the divisional round       

After a 23-17 victory at the Dallas Cowboys in the wild-card round, the San Francisco 49ers (12-7; 11-8 ATS) stunned the No. 1 seed in the NFC in the divisional round. Last Saturday, the Niners outlasted the Green Bay Packers as 6-point road underdogs, 13-10, and fully deserved their place in the AFC championship game.

The 49ers managed to keep Aaron Rodgers and Davante Adams in check, while on the other side of the ball, Robbie Gould hit both of his field-goal attempts, including the game-winner as the time expired. San Francisco’s offense has struggled mightily all game long. The Niners have to thank their special team for a massive six-yard TD of a blocked punt in the fourth quarter.

San Francisco gained only 212 all-purpose yards last weekend. Jimmy Garoppolo went 11-of-19 for 131 yards and an interception; Elijah Mitchell posted 17 carries for 53 yards, while Deebo Samuel recorded 83 yards from scrimmage. George Kittle had a couple of key catches down the stretch and finished with 63 yards on four receptions.

The Rams barely survived the divisional round          

The Los Angeles Rams (14-5; 10-9 ATS) easily defeated the Arizona Cardinals 34-11 in the wild-card round. The divisional round brought a much more exciting duel, as the Rams narrowly defeated the Tampa Bay Buccaneers 30-27.

Playing as a small 2.5-point road dog at Raymond James Stadium, Los Angeles nearly blew a 24-point second-half lead. The Rams turned the ball over a whopping four times, allowing the reigning champs to tie the game at 27-27 with 42 seconds left on the clock in the fourth quarter. Matt Gay decided the winner with a 30-yard field goal as the time expired.

Cam Akers fumbled twice and finished the divisional round with only 48 yards on 24 carries. Matthew Stafford completed 28 of his 38 passing attempts for 366 yards and a couple of touchdowns; Cooper Kupp had nine receptions for 183 yards and a TD, while Odell Beckham Jr. added six catches for 69 yards.


San Francisco:

  • 6-1 ATS in the last seven games overall
  • 4-1 ATS in the last five games on the road 

LA Rams:

  • 1-5 ATS in the last six games against San Francisco

San Francisco 49ers vs. Los Angeles Rams Pick

The 49ers have owned the Rams over the last three years, going 6-0 straight up and 5-1 ATS in the process. Back in the ultimate week of the 2021 regular season, the Niners overcame a 17-point deficit to beat the Rams 27-24 in overtime at SoFi Stadium.

Kyle Shanahan knows what his team needs to do in this matchup. The Niners will continue to run the pigskin as much as possible, while on the other side of the ball, they’ll try to disrupt the Rams’ passing game. The key to San Francisco’s success will be the pass rush. The Rams, on the flip side, need to deal with the 49ers at the line of scrimmage, and that’s something LA hasn’t done successfully in a while. 

Pick: Take San Francisco 49ers +3.5 at -110                    

The Total:

The under is 6-1 in San Francisco’s last seven outings and 4-2 in the previous six encounters between the 49ers and Rams. The total has gone under in four of the Rams’ last eight games overall, so I would stick with the betting trends and take the under.

The Rams will certainly try to speed up things. They lean on a fluid passing attack, but the Rams will have a tough job keeping the Niners’ front seven quiet. On the other side, the 49ers will desperately need to control the clock and keep Matthew Stafford on the sidelines as much as possible.

Pick: Go under 46.5 points at -110