The NFL betting action goes on for the final week of the regular season as all 32 teams take to the gridiron. This includes an NFC West showdown at SoFi Stadium in Los Angeles, so we bring you the best 49ers vs. Rams betting pick along with the latest odds update on Bookmaker Sportsbook.  The Rams are favored by 6.5-points.

San Francisco beat Los Angeles the last time these teams met, winning 31-10 on November 15. That was their fifth straight win against the Rams. QB Jimmy Garopollo is listed as questionable for San Francisco, as is Marcell Harris, Dre Greenlaw, Azeez Al-Shaair, and Jaquiski Tartt. The Rams have several key injuries at the running back position, including Cam Akers and Darrell Henderson.

49ers Shut Down Texans

The San Francisco 49ers (9-7) enter this contest as winners of six of their last eight games. The 49ers are 7-3 ATS in their last 10 games. San Francisco has been tough on the road the season, going 5-3 but, surprisingly, their only division victory this year was against the Rams.

San Francisco Rd. a tough defense in their win over Houston, holding the Texans to 15 first downs and 222 yards of total offense. Fred Warner had 15 tackles in the game and now leads the 49ers with 129 total tackles. Nick Bosa has been a quarterback’s worst nightmare, recording 15 of the 43 sacks recorded by the 49ers defense. San Francisco is allowing 21.3 points per game, 13th overall.

Trey Lance will remain at the quarterback position. He completed 16 of 23 passes for 249 yards and two scores against Houston. This is a team led by running back Elijah Mitchell, who has rushed for 878 yards and five touchdowns, averaging 4.7 yards per carry.

Rams Look to Lock No. 2 Spot

The Los Angeles Rams (12-4) enter this contest with the opportunity to earn the second seed in the NFC playoffs with a victory and a little help from Tampa Bay. Los Angeles is on a five-game winning streak and are 4-1 ATS over their last five games.

Los Angeles earned a one-point victory over Baltimore, rallying for 13 points in the final quarter to earn a 20-19 victory. Matthew Stafford had a big game, throwing for 309 yards and two touchdowns. Stafford is having an MVP type season, completing 67.3% of his passes for 4648 yards and 38 touchdowns. However, he has thrown 15 interceptions this year.

The Rams defense allowed 327 total yards against Baltimore but came up big when they needed to, creating an interception and a fumble recovery. Erin Donald leads the team with 12.5 sacks and Leonard Floyd is close behind with 9.5.


San Francisco:

  • 1-4 ATS in their last five games against NFC West opponents.
  • 2-5 ATS in their last seven games on field turf

Los Angeles:

  • 4-1 ATS in their last five games.
  • 5-2 ATS in their last seven games against NFC West teams.

San Francisco 49ers vs. Los Angeles Rams Pick

San Francisco handled Los Angeles the last time these teams met, but the stakes are a little different in this contest. The 49ers are not in need of a victory, as they match up well against whoever their first-round opponent may be. For Los Angeles, they are looking for as many home games as they can possibly get in the playoffs, so look for them to put in a more significant effort to earn the victory in this game. Plus, it is hard to go against the team that is playing so well right now.

Pick: Take Los Angeles Rams at -6.5.

The Total:

These teams have gone under in four of the last five meetings, but Los Angeles is only going to win this game if they can put up some solid offensive numbers against the 49ers. The Rams have scored at least 30 points in three of their last five games and have gone over 20 in five straight contests. San Francisco has scored at least 23 in seven of their last eight games. No one should expect a huge offensive showcase, but 47 points would not be surprising.

Pick: Go over 44.5.