The Sunday Night Football in the NFL is giving us this inter-conference encounter on Sunday, September 25, and here you can get the best 49ers vs. Broncos betting pick and odds.

Both San Francisco and Denver are looking to improve to a 2-1 record when they face at Empower Field at Mile High. The 49ers are slight -1.5 favorites on MyBookie Sportsbook, while the total is set at 45 points. These inter-conference rivals haven’t met since 2018.

49ers didn’t allow any surprises against the Seahawks at home

The San Francisco 49ers bounced back from a weak Week 1 display against the Chicago Bears with a 27-7 home victory over the divisional rivals Seattle Seahawks. The Niners had a 20-point lead at halftime and let the visitors make a comeback, thanks to good time management and excellent defense that limited the Seahawks to 216 yards and 14 first downs. In opposite, San Francisco totaled 373 yards and had 25 first downs.

Starting quarterback Trey Lance suffered an ankle injury early on and will miss the remainder of the season. Jimmy Garoppolo completed 13 of 21 passes for 154 yards and a touchdown, and he also added a TD on the ground. Jeff Wilson Jr. was the best running back in the game with 84 yards on 18 carries, while Brandon Aiyuk was the team’s leading receiver with 63 yards on five catches. Nick Bosa registered a couple of sacks, while Dre Greenlaw and Charvarius Ward had eight tackles apiece.

TE George Kittle has sat out the last two games with a groin injury, and it is undetermined if he will take the field Sunday versus the Broncos.

Broncos beat the Texans, not thanks to HC Hackett

The Denver Broncos responded to an unlucky defeat to the Seattle Seahawks in Week 1 and defeated the Houston Texans 16-9 at home. It was a sloppy victory for the Broncos, who still don’t look synchronized on offense, mostly thanks to head coach Nathaniel Hackett, who has a lot of things to improve before the Broncos can be considered as one of the AFC contenders.

Denver did collect 350 yards opposite Houston’s 234 and committed only one turnover, which is an improvement from Week 1 and two crucial turnovers against Seattle. Russell Wilson didn’t impress as he completed just 14 of 31 attempts for 219 yards, one touchdown, and one interception. Eric Saubert caught the lone TD pass, but Courtland Sutton was excellent through the air with 122 yards on seven receptions. Javonte Williams and Melvin Gordon III combined for 122 rushing yards. Dre’Mont Jones registered two sacks and was one of three Broncos defenders with six tackles in this win.

Justin Simmons is out with a quad injury, while Jerry Jeudy (chest), Pat Surtain II (shoulder), KJ Hamler (knee), and Josey Jewell (calf) are questionable to feature on Sunday against the 49ers.  


San Francisco:

  • 2-8 ATS in the last ten games played in Week 3


  • 4-1 SU in the last five games when playing at home against San Francisco

San Francisco 49ers vs. Denver Broncos Pick  

Jimmy Garoppolo is back under the center for the Niners and, unlike Russell Wilson, his chemistry with his offense is on a high level. Wilson struggled in the previous start and Denver is 0-5 in the red zone, while the team committed even 25 turnovers in two games, which is the franchise negative record in back-to-back games. Still, I believe Wilson can bounce back against his former divisional rivals and display a Pro Bowl-worthy performance on Sunday against the defense that allows the fewest yards in the NFL so far. Russell will become more familiar with the offense and the number of penalties will drop, so I am backing the Broncos here.

Pick: Take the Broncos at +1.5 (-110)

The Total

Both San Francisco and Denver allow 13.0 points on average after two games this season, and given how their respective offenses played so far, I don’t expect to see a high-scoring affair on Sunday. We may see a lot of run offense from each side, so don’t be surprised if we have only two or three touchdowns in the game. Under is 5-0 in the 49ers’ last five games overall; Under is 10-3 in the Broncos’ previous 13 games overall, while Under is 10-0-1 in Denver’s last 11 games after allowing less than 250 total yards in their previous game.Pick: Go Under 45.5 (-120)