The 2022 MLB season continues Tuesday, April 12, with 15 games on tap, including this NL West showdown at the Oracle Park in San Francisco, California so we have prepared the best Padres vs. Giants betting pick and odds.

This will be the second contest of this three-game series. San Diego won the first contest of this series, winning 4-2 on Monday, but San Francisco enters as the favorite at home on Bookmaker Sportsbook at -115. These teams have split the last 10 meetings.

Padres Rally Late to Down Giants

The San Diego Padres (4-1) rallied for runs in the seventh and ninth innings to down the San Francisco Giants, 4-2. The Padres have opened the season rolling on the road, winning four of the first five games. It is a great start considering that this team went 34-47 on the road last season.

Austin Nola hit his first homerun of the season and has driven in four runs through the first five games. Jurickson Profar added an RBI and now has seven total. The team is hitting .256, 10th overall, and have a solid OPS of .731, 12th overall. This is quite a run, considering that Fernando Tatis has not even played yet, so his return will really bolster this lineup.

The Padres are getting great pitching, fourth in the league in ERA at 2.66. They have an opponent batting average of .167, tops in MLB, posting a WHIP of 1.08. This is a quality staff and the team will go with Yu Darvish on Tuesday. Darvish looked great in his opening day start, allowing no hits and four walks in six innings. He earned a no decision, but clearly set the tone for this season with his outing.

Bullpen Struggles in Loss to Padres

The San Francisco Giants (2-2) rallied in the sixth inning to tie the score, but gave up runs in the seventh of the ninth to fall to San Diego. The Giants dominated last season, going 107-55, including 54-27 at home, but they are .500 through the first four home contests this season.

A troublesome bullpen has been the issue for this club, as they gave up two runs through the final four innings in the loss. That has dropped the team to 15th in bullpen ERA at 3.50, allowing seven runs in 18.0 innings despite posting a 1.11 WHIP. The starting staff has been solid however, ninth in ERA at 2.84, and they will send right-hander Alex Cobb to the mound on Tuesday to make his season debut. Cobb was 8-3 with a 3.76 ERA in 93.1 innings last season. He posted a 1.26 WHIP.

San Francisco got three hits from Brandon Belt, who reached base four times in the contest. Belt has been on fire for this team early on, posting a .417 batting average and a 1.250 OPS. He has been a major bright spot for a team that is struggling early on, as San Francisco is hitting .213 through the first four contests with just 12 runs scored. The team has flexed their muscles a bit, hitting three home runs.


San Diego Padres:

  • 4-0 in their last four games against NL West opponents.
  • 4-0 in their last four road games.

San Francisco Giants:

  • 1-4 in their last five games against teams with a winning percentage greater than 60%.

San Diego Padres vs. San Francisco Giants Pick

No one got off to a better start to the season than Yu Darvish, who tossed six no-hit innings in his debut. He has outstanding stuff, and is going to make it very difficult for this already struggling San Francisco offense to get things going. They enter with a .292 on-base percentage and a .339 slugging percentage, clearly not numbers you want against a dominant pitcher like Darvish.

San Diego is getting great support from their offense, scoring 24 runs through their first five games and they have 12 extra-base hits as well. Cobb has had to wait nearly a week before making his debut, so look for him to be a little shaky early on.

Pick: Take the San Diego Padres at -105

The Total:

If Darvish is anywhere near as good as he was in his debut, San Francisco is coming away with nothing more than a single run in this contest. Plus, Cobb pitched very well last year, so this should be a low-scoring game for about six innings.

The bullpens for both teams have been anything but lights out, however. San Francisco has a 3.50 bullpen ERA while San Diego was at 5.29, despite having a 3-1 record. This is where the runs are going to score, but still not enough to go over 7.5. Look for seven runs to be scored.

Pick: Go under 7.5.