Minnesota and Chicago lock horns in the AL Central showdown at Guaranteed Rate Field in Chicago on Tuesday night, so we have prepared the best Twins vs. White Sox betting pick along with the latest odds update on BetOnline Sportsbook.  

The Twins and White Sox meet for the second of a three-game set. Monday’s opener has been excluded from this preview, while the Twins swept the Chi Sox in a three-game series at Target Field in Minneapolis back in April. Chicago is a slight -129 home fave for Tuesday’s battle, and the totals sit at 9.0 runs. 

The Twins look for their second straight series win                                      

The Minnesota Twins haven’t been at their best over the last few weeks. They’ve gone 7-7 in the previous 14 games at any location while posting a strong 2.83 ERA, 1.07 WHIP, and .208 batting average against. However, the Twins’ offense has had ups and downs despite a solid .250/.304/.441 triple-slash. 

Last Sunday, Minnesota lost to Baltimore 3-1 but still won a three-game home set. The Twins have accounted for just eight runs against the Orioles’ pitching staff and scored only 25 runs in their previous seven outings. 

Chris Archer will take the mound Tuesday and meet the White Sox for the second time this season. The 33-year-old righty threw three innings in a no-decision against Chicago on April 24 and gave up a couple of earned runs on three hits and three walks. Archer is 2-3 with a 3.08 ERA and 1.25 WHIP in 15 starts (61.1 innings) in 2022. 

The White Sox just swept the Giants on the road         

The 38-39 Chicago White Sox carried a three-game winning streak into Monday night’s clash against the Twins. They were coming off a three-game road series versus the San Francisco Giants, and the White Sox won Sunday’s closer 13-4. 

Chicago was sitting at the third spot in the AL Central on Monday, a couple of games behind the Cleveland Guardians and 4.5 games off the 45-37 Minnesota Twins. The White Sox have won four of their previous five tilts while hitting a decent .288/.337/.393 with two home runs and 14 doubles across 191 at-bats. 

Michael Kopech will toe the slab Tuesday and face the Twins for the second time in 2022. The 26-year-old right-hander fired five scoreless frames in a no-decision at Target Field on April 22 while punching out seven. Kopech holds a 2-5 record in 14 starts (68 innings) this season, albeit with a firm 2.78 ERA and 1.03 WHIP. 



  • 2-9 in the last 11 road games against the White Sox 
  • 3-8 in the last 11 games against the AL Central 

Chi Sox:

  • 4-1 in the previous five games overall  
  • 7-2 in the last nine games against the AL Central 

Minnesota Twins vs. Chicago White Sox Pick 

Michael Kopech has been charged for a loss in three straight starts, surrendering 11 runs (ten earned) on 15 hits and seven walks across 16.1 innings pitched. I’m expecting to see some improvement this time around because the current Twins have a paltry two hits in 23 at-bats against Kopech. On the other side, Chris Archer has allowed just four runs over his previous four starts and 17 frames of work, but the current White Sox have 18 hits and .802 OPS in 56 at-bats against him. 

Hereof, I lean toward the White Sox. Both bullpens have done an excellent job in the last ten days, and we should see a tight battle down the stretch. Chris Archer has yet to get more than 15 outs in an outing this season, and he issued a whopping six walks through four innings last time out. 

Pick: Take Chicago White Sox at -129                                    

The Total:

The White Sox’s bullpen has compiled a 3.24 ERA, 1.92 FIP, and 10.8 K/9 over the last ten days and 25 innings of work while surrendering zero home runs. On the other side, the Twins’ bullpen has registered a 2.48 ERA, 3.34 FIP, 8.9 K/9, and 0.50 HR/9 across 36.1 innings in that span. 

Neither team has impressed at the plate lately, so I’m backing the under on the totals. Seven of the White Sox’s last ten games and six of the Twins’ previous seven have gone under the total. 

Pick: Go under 9.0 runs at -115