The MLB betting action continues Saturday, June 11, 2022, with the interleague showdown at Minute Maid Park in Houston, Texas, so we bring you the best Marlins vs. Astros betting pick along with the latest odds update on MyBookie Sportsbook

The Astros are listed as heavy -245 moneyline favorites with a total of 8.5 runs, while the Marlins are +200 road underdogs. Houston and Miami continue their three-game set, and Friday’s opener has been excluded from the analysis.   

The Marlins are on a ten-game road trip                                 

The Miami Marlins beat Washington 7-4 this past Thursday to sweep a three-game home series against the Nationals. It was their sixth victory in the previous nine outings, as the Marlins improved to 25-30 on the season. 

Miami has scored 62 runs during that nine-game stretch, slashing an excellent .287/.353/.452. On the pitching side of things, the Marlins have posted an underwhelming 4.72 ERA to go with a 1.26 WHIP and .237 batting average against. 

Braxton Garrett will get the starting call Saturday, his second of the season. Last Sunday, the 24-year-old lefty was charged for a loss in a 5-1 defeat to the San Francisco Giants, surrendering four earned runs on five hits and a walk across 3.1 innings of work. 

The Astros continue their six-game homestand                               

The Houston Astros fell to 36-21 on the season following a 6-3 defeat to the Seattle Mariners this past Wednesday. They dropped a three-game home set, losing their second straight Mariners series in just a couple of weeks. 

Houston has won seven of its previous ten contests. The Astros continue to lean on their pitching staff which owns the third-lowest ERA in the majors (3.01), while their lineup is scoring 4.11 runs per contest (22nd in the MLB). 

Framber Valdez will take the hill Saturday, searching for his sixth straight win. The 28-year-old left-hander has allowed only eight earned runs over his previous five starts and 36.2 innings of work. Valdez is 6-2 with a sharp 2.61 ERA, 3.33 FIP, and 1.13 WHIP in 11 starts (69 innings) in 2022. 



  • 3-9 in the last 12 games on the road  
  • 2-12 in the last 14 games against the American League 


  • 7-3 in the last ten games overall 
  • 6-0 in Framber Valdez’s last six starts  

Miami Marlins vs. Houston Astros Pick 

The Marlins are way more dangerous when batting against the righties. They own a horrible .206/.277/.320 slash line against the left-handed pitchers in 2022, so Framber Valdez should dominate this contest. 

On the other side, the Astros’ offense is underperforming, but it should get things going against Braxton Garrett. Also, the Marlins’ bullpen has recorded an awful 6.88 ERA and 4.76 FIP in the last ten days of action, so give me the Astros to cover a 1.5-run spread. 

Pick: Take Houston Astros -1.5 at -115                             

The Total:

I lean toward the under because of the Marlins’ inefficiency against the left-handed pitchers, but it’s hard to trust Braxton Garrett and the Marlins’ bullpen. Hereof, Houston to win remains my best Marlins vs. Astros betting pick. 

Six of Miami’s last nine games have gone over the total, but five of those nine tilts have come against the Nationals and Rockies. On the other side, the under is 11-3 in the Astros’ last 14 outings at Minute Maid Park.  

Pick: Go under 8.5 runs at -120