This MNF in the NFL is giving us a divisional rivalry game, and here you can get the best Rams vs. 49ers betting pick and odds for the clash that is scheduled for Monday, October 3.

Los Angeles is looking to extend the winning streak to three games when they take on San Francisco at Levi’s Stadium. The 49ers are slight -1.5 favorites on BetDSI Sportsbook, while the total is set at 42.5 points. These NFC rivals have met on three occasions in 2021 and the 49ers won two, but the Rams were better in the NFC Championship game.

Rams secured back-to-back wins

The Los Angeles Rams put the Week 1 loss to the Buffalo Bills behind and connected two victories against the Atlanta Falcons and Arizona Cardinals. The most recent one over the Cardinals was sweeter because it came on the divisional rival’s turf. The Rams’ defense prevailed in a 20-12 win, and even though Arizona had more total yards (365-339) and first downs (23-15), as well as possession, the visitors didn’t surrender a single touchdown.

Matthew Stafford had 18 completions out of 25 passes for 249 yards, no touchdowns, and no interceptions. The Bills collected exactly 100 rushing yards. Cam Akers rushed for 61 yards and a TD on 12 carries, while Cooper Kupp scored the first rushing touchdown of his career. Ben Skowronek and Tyler Higbee contributed with combined 127 yards on 12 catches. Derion Kendrick and Bobby Wagner were the most active on defense with nine tackles each.

C Brian Allen (knee) and WR Van Jefferson Jr. (knee) are out indefinitely and will not play on Monday against the 49ers.

49ers lost to the Broncos in a strange affair

The San Francisco 49ers fell short to the Denver Broncos on the road in one of the strangest games in recent years. The Niners had a 10-5 lead late in the fourth quarter, but the Broncos scored a leading touchdown and then didn’t allow San Francisco’s offense to even cross to their half of the field. The 49ers committed three turnovers opposite Denver’s none.  

Jimmy Garoppolo came as a deputy for injured starting QB Trey Lance and completed 18 of 29 passes for 211 yards, one touchdown, and one interception. Brandon Aiyuk got that lone TD pass, while Deebo Samuel led the team with 73 receiving yards on five receptions. Jeff Wilson Jr. was solid on the ground with game-high 75 yards on 12 rushes, but the team was limited to below 90 rushing yards. On defense, Dre Greenlaw registered a game-high ten tackles.

T Trent Williams sustained an ankle injury against the Broncos and will miss four to six weeks. LB Azeez Al-Shaair is out with an MCL sprain, while DT Arik Armstead (foot) is questionable to face the Rams on Sunday.


Los Angeles:

•            31-15-1 ATS in the last 47 vs. NFC rivals

•            4-1 ATS in the last five Monday games

San Francisco:

•            0-6 SU in the last six games played in Week 4

Los Angeles Rams vs. San Francisco 49ers Pick  

I know that this is a divisional tilt and that San Francisco beat Los Angeles twice last year, but the Rams are reigning champions, and I think they have what it takes to beat the 49ers and Jimmy Garoppolo here. The Niners have one of the least efficient offenses in the NFL that is averaging 15.7 ppg, while they are averaging only 172.7 passing yards per contest. The Rams have a more talented offense, starting with quarterback Matt Stafford. Their defense is relieved to know that it will not face Trent Williams, so Los Angeles’ pass rush could have a big game here.

Pick: Take the Rams at +1.5 (-110)

The Total

The 49ers have a top 3 defense in the NFL that is allowing 12.3 ppg, and they know that the only way to beat the Rams is a low-scoring affair. On the other side, San Francisco doesn’t have a good offense as it averages a miserable 15.7 ppg, so I doubt they will suddenly explode in this one. Under is 4-1 in the last five H2H meetings; Under is 7-2 in the previous nine H2H duels in San Francisco, while Under is 10-1 in the 49ers’ last 11 games overall.

Pick: Go Under 42.5 points (-110)