The Los Angeles Dodgers meet the Chicago White Sox for the first time since 2017. Tuesday night’s opener of their three-game series at Guaranteed Rate Field in Chicago has been excluded from the analysis, as we’re taking a closer look at Wednesday’s middle game to get you the best Dodgers vs. White Sox betting pick and odds.  

According to MyBookie Sportsbook, the Dodgers are -165 road favorites for Wednesday’s clash. The White Sox are +140 moneyline underdogs, while the totals sit at 8.5 runs.  

The Dodgers have dropped five of their previous seven contests                               

After suffering a shocking sweep in a three-game home series against the Pittsburgh Pirates, the Los Angeles Dodgers split a four-game home set against the New York Mets. They carried a 35-19 record into the interleague series versus the White Sox, sitting atop of the NL West. 

The Dodgers boast the highest-scoring offense in the majors (5.37 runs per game) to go with the highest OPS (.761) and the second-lowest ERA (2.91). Tony Gonsolin will get the starting call Wednesday in Chicago, and the 28-year-old righty is undefeated in 2022. 

Gonsolin has gone 6-0 with a sparkling 1.59 ERA and 0.88 WHIP through his first ten starts (51 innings) of the season. Last Thursday, Tony pitched a gem in a 2-0 victory to the Mets, allowing only two hits and a walk across six shutout innings. 

The White Sox hope to get things going at home                             

The Chicago White Sox beat Tampa Bay 6-5 this past Sunday to clinch a three-game set at Tropicana Field. It was their second win in a row and third in their previous nine games overall, and the Chi Sox have also gone 3-6 over their previous nine showings at Guaranteed Rate Field. 

The White Sox are still without Tim Anderson (groin) and Eloy Jimenez (hamstring), who are a big part of their offense. Chicago is tallying only 3.65 runs per game (27th in the majors), and over the last couple of weeks, the White Sox have slashed .256/.309/.379. 

Their pitching staff is not helping a lot. The White Sox have registered a miserable 5.88 ERA, 1.73 WHIP, and .293 batting average against in the last 11 games overall. Johnny Cueto will toe the slab Wednesday, and the veteran righty is 0-2 with a 2.92 ERA and 1.26 WHIP in four starts (24.2 frames) this season. 


LA Dodgers: 

  • 8-2 in the last ten games on the road 
  • 6-2 in the last eight games against the White Sox 
  • 5-1 in Tony Gonsolin’s last six starts 

Chi Sox:

  • 3-6 in the last nine games overall 
  • 3-6 in the last nine games at home   

Los Angeles Dodgers vs. Chicago White Sox Pick 

Tony Gonsolin will have to slow down eventually, but until that happens, I’m rolling with the crafty righty. On the other side, Johhny Cueto will have a mountain to climb against the Dodgers’ powerful lineup. 

The current Dodgers have a .984 OPS in 123 at-bats against Cueto, who’s yielded nine runs (eight earned) over his last two starts and 12.2 innings of work. Also, the Dodgers are killing it at the plate against the righties in 2022, racking up a .253/.337/.438 triple-slash and a 122 OPS+.  

Pick: Take Los Angeles Dodgers at -165                            

The Total:

The White Sox own an awful .231/.285/.338 slash line against the right-handed pitchers in 2022. I wouldn’t be surprised if Tony Gonsolin shuts them down. Hereof, I lean toward the under, but the Dodgers’ lineup could easily destroy Johnny Cueto. 

The Dodgers’ bullpen has struggled a bit in the last ten days, tallying a 4.32 ERA and .317 BABIP. On the other side, the White Sox’s relievers have recorded a sharp 2.60 ERA and 3.03 FIP, though with a .324 BABIP. 

Pick: Go under 8.5 runs at -105