The Week 5 of college football is offering a lot of exciting matchups on Saturday, October 1, including this Big 12 encounter, and here you can get the best Cyclones vs. Jayhawks betting pick and odds.

Kansas is hoping to maintain its perfect record when Iowa State visits David Booth Kansas Memorial Stadium on Saturday. The Cyclones are -3.5 favorites on MyBookie Sportsbook, while the total is set at 57.5 points. These conference foes have faced once in 2021, and the Cyclones dismantled the Jayhawks 59-7 in Iowa.

Cyclones lost the Big 12 opener to Baylor at home

The Iowa State Cyclones suffered their first loss of the season as they fell short to the Baylor Bears 31-24 at home. It was the opening game of the conference play, and the home side failed to cover a -2.5 spread. Iowa State committed two turnovers opposite Baylor’s zero, while the Bears had six first (23-17) downs more than the Cyclones.

Hunter Dekkers completed 23 of 36 passes for 284 yards, two touchdowns, and two interceptions. Dimitri Stanley and Jirehl Brock caught those TD passes, while Jaylin Noel led all the receivers with 120 yards on seven receptions. Brock also added a rushing touchdown and had 74 yards on the ground on 14 carries. T.J. Tampa, O’Rien Vance, and Gerry Vaughn led the team with eight tackles each.

OL Jake Remsburg has sat out the past four games due to a knee injury, and it is unclear if he will suit up Saturday against Kansas.

Jayhawks beat Duke to maintain a perfect record

The Kansas Jayhawks won all four games to open the new NCAAF season and covered all four, including the most recent one against the Duke Blue Devils. Kansas had a 15-point lead after three quarters and didn’t allow the Blue Devils to make a comeback in the final 15 minutes in a 35-27 victory.

Jalon Daniels was impressive with 19 completions on 23 attempts for 324 yards and four touchdowns. Daniels also added a rushing TD and led the team in rushing yards with 83 on 11 carries, while he connected with four different receivers in the end zone: Lawrence Arnold, Daniel Hishaw Jr, Luke Grimm, and Trevor Kardell. Ra’Mello Dotson was the most active on defense with team-high nine tackles.

WR Trevor Wilson is serving a suspension for an off-field incident, and there is no timetable for return. He will not be going to play on Saturday against the Cyclones.


Iowa State:

  • 2-5 ATS in the last seven conference games
  • 1-5 ATS in the last six vs. a team with a winning record


  • 7-0 ATS in the last seven games overall
  • 5-0 ATS in the last five games following an ATS win
  • 4-0 ATS in the last four conference games

Iowa State Cyclones vs. Kansas Jayhawks Pick  

The Cyclones do have a top 20 defense, but I think they will find it hard to defend a two-way quarterback Jalon Daniels, who already has over 1,200 combined yards (passing and rushing). Kansas is a top 10 in run offense and top 20 with 47.0 points scored per game, so the Cyclones will have a lot of work to do to justify their role as a favorite. I don’t think they will make it after last week’s home loss to Baylor, and I am backing the Jayhawks to make a little surprise here.

Pick: Take the Jayhawks at +3.5 (-110)

The Total

Kansas will eat a lot of the game clock as they do prefer to run the ball, and although I have no doubt they will be able to move the chains, I don’t expect to see a high-scoring game here. The Jayhawks did score 35+ points in each of their four games this season, but that’s not going to be easy against one of the best defenses in the country. Under is 18-8-1 in the Cyclones’ last 27 road games; Under is 7-3 in Iowa State’s previous ten games following an ATS loss, while Under is 4-1 in the Jayhawks’ last five vs. a team with a winning record.Pick: Go Under 57.5 points (-110)