The NFL season continues with Week 7 games, including this divisional tilt in Nashville, TN, on Sunday, October 23, so make sure you check out the best Colts vs. Titans betting pick and odds.

Tennessee is hoping to record its fourth consecutive win when they welcome Indianapolis at Nissan Stadium. The Titans are slight -2.5 favorites on BookMaker Sportsbook, while the total is set at 43.5 points. These AFC South foes have already met this season, and the Titans won that game 24-17 in Indianapolis.

Matt Ryan led a game-winning drive against the Jaguars

The Indianapolis Colts (3-2-1, 3-3 ATS) secured their second straight win after defeating the divisional rivals Jacksonville Jaguars 34-27 at home. The visitors had a 14-3 lead early on and scored a late touchdown to take a 27-26 lead, but Matt Ryan led his team to a comeback victory as he threw a TD pass to Alec Pierce with only 17 seconds remaining. Indianapolis also converted a 2-point attempt to seal the deal. The Colts did allow season-high 27 points, but they also scored a season-high 34.

Matt Ryan had the best game in the Colts uniform since his arrival from Atlanta. He completed 42 of 58 passes for 389 yards and three touchdowns. Parris Campbell, Alec Pierce, and Jelani Woods were on the receiving end of those TD passes, while Michael Pittman Jr. led all the receivers with 134 yards on 13 receptions (16 targets). Indy didn’t use the run offense a lot, but Deon Jackson did find the end zone and collected team-high 42 yards on 12 carries. Defensively, Bobby Okereke and Zaire Franklin were rock-solid as they combined for 25 tackles.

LB Shaquille Leonard (concussion), WR Keke Coutee (concussion), RB Nyheim Hines (concussion), and RB Jonathan Taylor (ankle) are questionable to feature on Sunday against Tennessee.

Titans won three in a row

The Tennessee Titans (3-2, 3-2 ATS) opened the season with a pair of defeats but responded with three consecutive wins, including the most recent one over the Washington Commanders 21-17 on the road. Although Washington was much better in total yards (385-241), the Titans scored a game-winning TD with a bit more over a minute to go, and then made a crucial interception in the end zone to secure a W.

Ryan Tannehill completed 15 of 25 passes for 181 yards and one touchdown. Dontrell Hilliard caught that lone TD pass, while Nick Westbrook-Ikhine led the team in receiving yards with 72 on two receptions. As usual, Tennessee was much more active on the ground and scored a couple of rushing touchdowns through Derrick Henry, who registered a game-high 102 yards on 28 carries. David Long Jr. recorded that crucial pick in dying moments, while he also led the Titans with 12 tackles.

LB Bud Dupree (hip), LB Zach Cunningham (elbow), and S Amani Hooker (concussion) are questionable to face the Colts on Sunday.



  • 1-4 ATS in the last five vs. AFC South rivals
  • 1-5 ATS in the last six games against Tennessee


  • 7-3 ATS in the last ten games following an ATS win
  • 5-2 ATS in the last seven vs. AFC South opponents
  • 5-1-1 ATS in the last seven games following a bye week

Indianapolis Colts vs. Tennessee Titans Pick  

Both teams will enter this divisional clash in fine form, but I am giving an advantage to the Titans, who already beat the Colts a few weeks ago, and are on a three-game winning streak. Also, Tennessee is coming off a bye week; the hosts had more than enough time to prepare for this game, and I believe that will help them to get a W on Sunday. Matt Ryan had a great game last week, and considering that Indianapolis has the fifth-best pass offense that averages 266.2 yards per game, while Tennessee has the worst pass defense in the league that allows 287.6 ypg, I think the visitors will get a chance here. However, Ryan Tannehill and Derrick Henry have the ability to hurt the Colts with play-action and powerful running, and I am sure the hosts will control the tempo of the game. It will be a tight one, but I am going with the Titans to get an edge.

Pick: Take the Titans at -2.5 (-110)

The Total

Last time out when these rivals met, I backed Under and it did pay off, so I have no intention of changing my mind for this encounter. These teams are not even in the top 20 when it comes to points per game and are combining for 36.4 ppg. Tennessee will eat a lot of a game clock with Tannehill’s short passes and Henry’s frequent runs. Under is 10-1 in the Colts’ last 11 games overall; Under is 6-0 in Indianapolis’ previous six road games, while Under is 9-1 in the Colts’ last ten vs. AFC rivals. Also, Under is 8-3 in the Titans’ last 11 games overall, while Under is 6-1 in Tennessee’s previous seven home games.

Pick: Go Under 43.5 points (-110)