The NFL action on Sunday, December 4, will close with another inter-conference clash, so make sure you don’t forget to take a look at the best Colts vs. Cowboys betting pick and odds.

Dallas is looking for the third win in a row when they host Indianapolis at AT&T Stadium. The Cowboys are 11-point favorites on MyBookie Sportsbook, while the total is set at 43.5 points. These inter-conference rivals haven’t met since 2018.

Colts disappointed against the Steelers at home

The Indianapolis Colts (4-7-1, 5-7-0 ATS) suffered the fifth defeat in six games and the second in a row at home. Following a brave display and a tight 17-16 loss to the Philadelphia Eagles, the Colts disappointed in a 24-17 home loss to the Pittsburgh Steelers. Indianapolis was down 16-3 at halftime but managed to score a pair of touchdowns in the third quarter to get a lead. However, the visitors responded in the fourth and kept the Colts off the scoreboard to secure a victory.

Matt Ryan completed 22 of 34 passes for 199 yards, one touchdown, and one interception. Michael Pittman Jr. caught that lone TD pass from Ryan and had 61 yards on seven receptions, while Jelani Woods chipped in a game-high 98 yards on nine catches. Jonathan Taylor was the best running back in this game as he ended with 86 yards and a touchdown on 20 carries. Yannick Ngakoue was credited with two of the Colts’ three sacks, while Zaire Franklin and Kenny Moore II combined for 21 tackles.

CB Kenny Moore II (shin), P Rigoberto Sanchez (Achilles), S Armani Watts (ankle), and LB Shaquille Leonard (back) are out indefinitely. DE Kwity Paye (ankle) and TE Kylen Granson (illness) are questionable to play on Sunday against Dallas.

Cowboys beat the Giants in a divisional rivalry clash

The Dallas Cowboys (8-3-0, 7-4-0 ATS) didn’t allow their heads to drop following a historic 40-3 road victory over the Minnesota Vikings. They beat the divisional foes New York Giants 28-20 at home even though the visitors had a 13-7 lead at halftime. Dallas played much better in the second 30 minutes and surrendered only seven points. The Cowboys dominated the total yards (430-300), first downs (26-21), and possession (34:09-25:51).

Dak Prescott completed 21 of 30 for 261 yards, two touchdowns, and two interceptions. He connected with Dalton Schultz on two occasions in the end zone; Michael Gallup and Jake Ferguson combined for 120 yards on eight receptions, while CeeDee Lamb had a game-high 106 yards on six catches. Ezekiel Elliott was solid on the ground with 92 rushing yards and a score on 16 attempts, while rookie tight end Peyton Hendershot registered the first rushing TD in his career. On defense, Micah Parsons had a pair of sacks, while Leighton Vander Esch led the team with eight tackles.

DT Johnathan Hankins (illness) and LB Anthony Barr (hamstring) are questionable to face the Colts on Sunday.



  • 2-5 ATS in the last seven road games
  • 2-4 ATS in the last six games overall


  • 7-3 ATS in the last ten games overall
  • 4-1 ATS in the last five home games
  • 13-3 ATS in the last 16 vs. a team with a losing record
  • 5-0 ATS in the last five games following an ATS loss

Indianapolis Colts vs. Dallas Cowboys Pick  

The Colts did start to play better since the appointment of Jeff Saturday as their interim head coach but they are still not good enough to fight with the big boys. Following a home defeat to Pittsburgh, I don’t expect Indianapolis to bounce back here. One of the worst offenses in the NGL that is averaging just 15.8 points per game is facing the second-best defense in the league that is allowing 17.0 ppg. Dallas also has a top-10 offense that is scoring 25.4 ppg, so I don’t think the visitors have a chance in this one. I am going with the Cowboys to secure a comfortable win.

Pick: Take the Cowboys at -9.5 (-130)

The Total

The Colts managed to score more than 20 points only once on the road this season and once in the last six overall, so I seriously doubt they will score more than 14 on Sunday in Dallas. The Cowboys have the best pass defense in the NFL that is surrendering just 177.7 yards per game to the opposing receivers. Indianapolis, who prefers pass offense, will find it hard to move the chains. Under is 4-1 in the last five H2H meetings; Under is 14-3 in the Colts’ previous 17 games overall, while Under is 8-1 in Indianapolis’ last nine road games.

Pick: Go Under 45.5 points (-130)