Jon Lester (4-2, 1.88 ERA) starts for the Chicago Cubs (29-11) as they square off against Matt Cain (0-5, 5.87 ERA) and the San Francisco Giants (25-19) in the second of a three-game series at AT&T Park. The Cubs won the last game 8-1, and Chicago leads the series 1-0. Action begins at 7:15 p.m. ET on Saturday, May. 21 and can be seen on FOX.

Cain pitched 7.0 innings in his most recent start, surrendering one run, striking out five and walking two in a 2-1 win over the Diamondbacks. Brandon Belt (.294, 20 Rs, 4 HRs, 22 RBIs) went 1 for 4 yesterday. Lester went 6.2 innings, surrendering one run, striking out nine and walking two in a 2-1 defeat to the Pirates in his last outing. Anthony Rizzo (.253, 29 Rs, 11 HRs, 34 RBIs, 2 SBs) went 1 for 5 yesterday.

The Cubs are a -155 favorite and the total is 7.5.

Pick - CHC

Notes

When leading after seven innings, Chicago is 16-3, while San Francisco is 8-6.

The Cubs are coming into this game after allowing two walks during their last outing. The Giants have a 4-7 record when opponents give up two walks or less.

When they outhit their opponents, the Cubs are 24-2. The Giants have a 17-0 record when outhitting opponents.

Ranking seventh, San Francisco is in the top 10 of the league in runs, scoring 192 this season. Chicago ranks in the top five at third with 229.

Ranking 13th, San Francisco is in the top half of the league for its on-base plus slugging percentage (.733). Chicago ranks in the top five at third with an OPS of .792.

The Cubs are 12-8 in games where they allow one or more home runs. The Giants are 8-16 when they allow at least one homer.