The World Champion San Francisco Giants got a couple of gifts on their way toward winning the first game of an interleague series with the Cleveland Indians Friday night. So San Fran will be looking to extend its winning streak to four when the teams meet again Saturday afternoon at AT&T Park (4:10 pm Eastern, Fox).

The Giants won the opener of this series Friday night, rallying from down 3-0 to win 4-3, getting three unearned runs after a couple of errors by Indians 1B Carlos Santana and four-plus hitless innings from their bullpen.

So San Francisco sits in second place in the NL West, a half-game back of first-place Arizona. Cleveland, meanwhile, which has lost three of its last four, leads the AL Central by one game over second-place Detroit.

The Giants are now 22-13 at home this season, while the Tribe is 16-20 on the road.

On the injury front Cleveland lost OF Shin-Soo Choo to the disabled list when he got hit by a pitch Friday night and had his thumb broken.

On the other side of this matchup the Giants are now 15-13 since losing C Buster Posey for the season to a broken leg.

Justin Masterson (5-5, 3.18) gets the start for Cleveland Saturday against Matt Cain (6-4, 3.44) for San Francisco.

Masterson won his first five starts this year but hasn't won since. He had a couple of rough outings a couple of weeks ago. but over his last three starts he's allowed six earned runs on 29 baserunners (hits + walks) in 19 1/3 innings pitched. Masterson's last three starts have played under the posted totals, as have six of his last seven outings.

Masterson has never started a game vs. the Giants.

Cain has three quality starts over his last four outings, allowing eight ER on 27 baserunners in his last 29 1/3 IP. Five of his last six starts have played under the totals.

Cain hasn't faced Cleveland since 2008.

The over/unders are 36-34 in Indians games this season (excluding pushes), 28-43 in Giants games, and 11-22 in Giants home games, which have averaged 6.1 runs per, lowest among all ML ballparks.

Despite being eight games above .500 San Francisco ranks dead last in baseball in scoring at 3.4 runs per game. And they've been held to two runs or fewer in six of their last eight games.

As of Saturday morning is listing San Fran as a -133 favorite for Saturday's game, with an over/under of 6.5. is offering Cleveland at +125.

These two teams met most recently back in 2008, when the Giants took two of three games in an interleague series in Cleveland.