A couple of very hot pitchers hook up in one of those National League West rivalry bouts Tuesday when Matt Cain and the San Francisco Giants go against Tim Stauffer and the San Diego Padres in game two of a four-game series at AT&T Park (10:15 pm Eastern).

As of Tuesday morning Sportsbook.com is listing the Giants as -160 favorites for Tuesday night's game, the Padres at +140, with an over/under of six.

The Pads won the opener of this series Monday 5-3, knocking Giants ace Tim Lincecum out after five innings. The victory was San Diego's ninth in its last 12 games, while San Fran has lost four of its last six.

So heading into Tuesday's play San Francisco, at 48-38, sits atop the NL West, two games ahead of the second-place Arizona Diamondbacks, while San Diego, at 39-47, occupies fourth place, nine games back of the Giants.

Stauffer (4-5, 2.97) has put together a streak of five straight quality starts, allowing just four earned runs on 23 hits in his last 36 innings of work, walking six and striking out 33. On the season he owns a 1.19 WHIP and an 88/25 strikeout-to-walk ratio. San Diego is 9-8 in Stauffer's starts this season, the over/unders 7-9.

Stauffer has started three times vs. San Fran over the last two seasons, allowing five ER on 14 hits in 17 IP.

Cain (7-4, 3.02) has strung together three consecutive quality starts, giving up just one ER on 11 hits in his last 21 IP. For the season he owns a 1.09 WHIP and a 95/29 K/BB ratio. The Giants are 11-6 in Cain's starts this year, the over/unders 6-11.

But Cain hasn't exactly had great success against the Padres recently; in his five starts last year vs. the Padres Cain gave up 18 ER on 33 hits in 30 2/3 IP.

San Diego is a very respectable 20-20 on the road this season, while San Fran is 24-14 at home.

The over/unders are 39-43 in Padres games this season, 32-48 in Giants games, and 12-24 in games played at AT&T Park.

San Diego gave San Francisco headaches last year, taking the season series 12 games to six. And neither team is an offensive powerhouse. So as for Tuesday's game we'll take the price and go with San Diego getting +140.